Reactome | IL17A [extracellular region]

IL17A [extracellular region]

Stable Identifier

R-HSA-447093

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Interleukin-17A, IL17_HUMAN, CTLA8

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        SARS-CoV-2-host interactions (Homo sapiens)
        
        SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
        
        IL17RA and IL17RC bind IL17A dimer,IL17F dimer,IL17A:IL17F (Homo sapiens)
        
        IL17A dimer,IL17F dimer,IL17A:IL17F [extracellular region] (Homo sapiens)
        
        IL17A dimer [extracellular region] (Homo sapiens)
        
        IL17A [extracellular region] (Homo sapiens)
        
        IL17A:IL17F [extracellular region] (Homo sapiens)
        
        IL17A [extracellular region] (Homo sapiens)
        
        IL17RA:IL17RC:IL17A dimer,L17F dimer,IL17A:IL17F [plasma membrane] (Homo sapiens)
        
        IL17A dimer,IL17F dimer,IL17A:IL17F [extracellular region] (Homo sapiens)
        
        IL17A dimer [extracellular region] (Homo sapiens)
        
        IL17A [extracellular region] (Homo sapiens)
        
        IL17A:IL17F [extracellular region] (Homo sapiens)
        
        IL17A [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16552 IL17A

Gene Names

IL17A, CTLA8, IL17

Chain

signal peptide:1-23, chain:24-155

Reference Genes

BioGPS Gene:3605 IL17A

COSMIC (genes):IL17A IL17A

CTD Gene:3605 IL17A

dbSNP Gene:3605 IL17A

ENSEMBL:ENSG00000112115 IL17A

HGNC:5981 IL17A

KEGG:hsa:3605 IL17A

Monarch:3605 IL17A

NCBI Gene:3605 IL17A

OMIM:603149 IL17A

UCSC:Q16552 IL17A

Reference Transcript

RefSeq:NM_002190.2 IL17A

Other Identifiers

11732112_at

11732113_at

1359_at

17009567

208402_PM_at

208402_at

216876_PM_s_at

216876_s_at

2910166

2910167

2910169

2910170

2910173

2910174

3605

8120210

A_14_P108234

A_23_P332820

GE59087

GO:0002225

GO:0002250

GO:0002376

GO:0005125

GO:0005515

GO:0005576

GO:0005615

GO:0006355

GO:0006915

GO:0006954

GO:0006955

GO:0007219

GO:0007267

GO:0008219

GO:0009611

GO:0009897

GO:0010467

GO:0012501

GO:0022600

GO:0023052

GO:0030154

GO:0030216

GO:0032731

GO:0032735

GO:0032739

GO:0032747

GO:0032755

GO:0032760

GO:0038173

GO:0042803

GO:0043616

GO:0045087

GO:0045672

GO:0045944

GO:0046982

GO:0048018

GO:0048870

GO:0050829

GO:0050830

GO:0050832

GO:0060729

GO:0071347

GO:0072537

GO:0097400

GO:0097530

GO:0098542

GO:0098772

GO:0106015

GO:1900017

GO:1903348

GO:2000340

HMNXSV003047848

Hs.41724.1.S1_3p_a_at

ILMN_1774983

PH_hs_0003084

TC06000652.hg

U32659_at

g4504650_3p_at

Participates

as a member of

STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)

as a component of

Cross References

RefSeq

NP_002181.1

OpenTargets

ENSG00000112115

ENSEMBL

ENSP00000497968, ENST00000648244

HPA

ENSG00000112115-IL17A

PRO

Q16552

Pharos - Targets

Q16552

GlyGen

Q16552

PDB

7UWN, 8DYH, 8DYF, 7UWM, 8CDG, 8DYG, 5N92, 6WIO, 5HI4, 7AMA, 8USS, 2VXS, 7Z2M, 8DYI, 5NAN, 4HSA, 7ZAN, 5VB9, 5N7W, 7WKX, 8USR, 4QHU, 8DY1, 6WIR, 5HI5, 8B7W, 7AMG, 5HI3, 8DY5, 5HHX, 5HHV, 4HR9

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96F46 IL17RA	1	IL17RA [plasma membrane] (R-HSA-447176)	0.527	2
UniProt:P60568 IL2	1	IL2 [extracellular region] (R-HSA-447099)	0.527	3