TRAF6 binding leads to IRAK1:TRAF6 release

Stable Identifier
R-HSA-446894
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
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MyD88 and Tollip only bind to non-phosphorylated IRAK1 (Wesche et al. 1997) so hyper-phosphorylated IRAK1 is predisposed to release from the receptor complex, a key step in this signaling cascade. It is believed that the interaction of IRAK1 with TRAF6 enables the release of IRAK1:TRAF6 from the receptor (Gottipati et al. 2007). Though released from the receptor complex, IRAK1:TRAF6 remains associated with the membrane, perhaps due to subsequent interaction with the TAK1 complex (Dong et al. 2006).

Literature References
PubMed ID Title Journal Year
17890055 IRAK1: a critical signaling mediator of innate immunity

Gottipati, S, Rao, NL, Fung-Leung, WP

Cell Signal 2008
Participants
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This event is regulated
Negatively by
Orthologous Events
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