Hyperphosphorylated IRAK1 associates with TRAF6

Stable Identifier
R-HSA-446862
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Hyperphosphorylated IRAK1 associates with TRAF6
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Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002).
Literature References
PubMed ID Title Journal Year
8837778 TRAF6 is a signal transducer for interleukin-1

Cao, Z, Kurama, T, Xiong, J, Takeuchi, M, Goeddel, DV

Nature 1996
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Orthologous Events
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Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2009-11-18)
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