Reactome | Hyperphosphorylated IRAK1 associates with TRAF6

Hyperphosphorylated IRAK1 associates with TRAF6

Stable Identifier

R-HSA-446862

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Hyperphosphorylated IRAK1 associates with TRAF6

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Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002).

Literature References