Hyperphosphorylated IRAK1 associates with TRAF6

Stable Identifier
R-HSA-446862
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002).

Literature References
PubMed ID Title Journal Year
8837778 TRAF6 is a signal transducer for interleukin-1

Cao, Z, Xiong, J, Takeuchi, M, Kurama, T, Goeddel, DV

Nature 1996
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created