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Association of PARVA with TESK1
Stable Identifier
R-HSA-446372
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
Association of PARVA with TESK1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The association of PARVA with TESK1 appears to suppress cell spreading (Lalonde et al. 2005). TESK1 can phosphorylate cofilin and promote F-actin polymerization and cell spreading (Tsumura et al., 2005 ; Toshima et al., 2001; Leeksma et al., 2002). PARVA associates with testicular protein kinase 1 (TESK1) and inhibits its activity (Lalonde et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15817463
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin
Bouverat, BP
,
Brown, MC
,
Turner, CE
,
LaLonde, DP
J Biol Chem
2005
Participants
Input
PARVA [cytosol]
(Homo sapiens)
TESK1 [cytosol]
(Homo sapiens)
Output
PARVA:TESK1 [cytosol]
(Homo sapiens)
Participates
as an event of
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
Orthologous Events
Association of PARVA with TESK1 (Bos taurus)
Association of PARVA with TESK1 (Canis familiaris)
Association of PARVA with TESK1 (Danio rerio)
Association of PARVA with TESK1 (Drosophila melanogaster)
Association of PARVA with TESK1 (Gallus gallus)
Association of PARVA with TESK1 (Mus musculus)
Association of PARVA with TESK1 (Rattus norvegicus)
Association of PARVA with TESK1 (Sus scrofa)
Authored
Matthews, L (2009-10-12)
Reviewed
Wu, C (2009-11-12)
Created
Matthews, L (2009-11-12)
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