Reactome | PARVA associates with Paxillin

PARVA associates with Paxillin

Stable Identifier

R-HSA-446322

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-extracellular matrix interactions (Homo sapiens)
    - Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
      - PARVA associates with Paxillin (Homo sapiens)
    - Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
      - PARVA associates with Paxillin (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The focal adhesion protein alpha-parvin, interacts with paxillin, through the C-terminal CH-containing fragment of the alpha-parvin and paxillin LD motif (Wang et al., 2008; Lorenz et al., 2008). This interaction likely contributes to the localization of the PINCH-ILK-parvin complexes to focal adhesions.

Literature References

PubMed ID	Title	Journal	Year
18940607	Structural analysis of the interactions between paxillin LD motifs and alpha-parvin Lowe, ED, Hoellerer, MK, Campbell, ID, Vakonakis, I, Lorenz, S, Noble, ME	Structure	2008
18508764	The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly Gronenborn, A, Fukuda, K, Byeon, IJ, Velyvis, A, Wu, C, Qin, J, Wang, X	J Biol Chem	2008