Reactome | PARVA associates with Paxillin

PARVA associates with Paxillin

Stable Identifier

R-HSA-446322

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Locations in the PathwayBrowser

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Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Cell-extracellular matrix interactions (Homo sapiens)
    - Localization of the PINCH-ILK-PARVIN complex to focal adhesions (Homo sapiens)
      - PARVA associates with Paxillin (Homo sapiens)
    - Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
      - PARVA associates with Paxillin (Homo sapiens)

General

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The focal adhesion protein alpha-parvin, interacts with paxillin, through the C-terminal CH-containing fragment of the alpha-parvin and paxillin LD motif (Wang et al., 2008; Lorenz et al., 2008). This interaction likely contributes to the localization of the PINCH-ILK-parvin complexes to focal adhesions.

Literature References

PubMed ID	Title	Journal	Year
18508764	The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly Wang, X, Fukuda, K, Byeon, IJ, Velyvis, A, Wu, C, Gronenborn, A, Qin, J	J Biol Chem	2008
18940607	Structural analysis of the interactions between paxillin LD motifs and alpha-parvin Lorenz, S, Vakonakis, I, Lowe, ED, Campbell, ID, Noble, ME, Hoellerer, MK	Structure	2008