Reactome | Addition of the first mannose to the N-glycan precursor by ALG1

Addition of the first mannose to the N-glycan precursor by ALG1

Stable Identifier

R-HSA-446218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Addition of the first mannose to the N-glycan precursor by ALG1

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

A mannose is added to the N-glycan precursor via a beta-1,4 linkage. The reaction is catalyzed by ALG1 (Takahashi T et al, 2000). Defects in ALG1 lead to congenital disorder of glycosylation type 1K (CDG1K) (Schwarz et al. 2004; Kranz et al. 2004; Grubenmann et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14709599	Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik Hennet, T, Mayatepek, E, Frank, CG, Matthijs, G, Grubenmann, CE, Schollen, E, Berger, EG, Hülsmeier, AJ, Aebi, M	Hum Mol Genet	2004
14973782	Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I Denecke, J, Gudowius, S, Sohlbach, K, Rossi, R, Meinhardt, F, Lehle, L, Jeske, S, Marquardt, T, Kranz, C	Am J Hum Genet	2004
14973778	Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik Lübbehusen, J, Körner, C, Dorland, B, Lehle, L, von Figura, K, Thiel, C, Schwarz, M, de Koning, T	Am J Hum Genet	2004
10704531	Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1 Takahashi, T, Nishikawa, Y, Honda, R	Glycobiology	2000