Reactome | Addition of the first mannose to the N-glycan precursor by ALG1

Addition of the first mannose to the N-glycan precursor by ALG1

Stable Identifier

R-HSA-446218

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

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Addition of the first mannose to the N-glycan precursor by ALG1

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A mannose is added to the N-glycan precursor via a beta-1,4 linkage. The reaction is catalyzed by ALG1 (Takahashi T et al, 2000). Defects in ALG1 lead to congenital disorder of glycosylation type 1K (CDG1K) (Schwarz et al. 2004; Kranz et al. 2004; Grubenmann et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14709599	Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik Grubenmann, CE, Frank, CG, Hülsmeier, AJ, Schollen, E, Matthijs, G, Mayatepek, E, Berger, EG, Aebi, M, Hennet, T	Hum Mol Genet	2004
14973782	Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I Kranz, C, Denecke, J, Lehle, L, Sohlbach, K, Jeske, S, Meinhardt, F, Rossi, R, Gudowius, S, Marquardt, T	Am J Hum Genet	2004
14973778	Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik Schwarz, M, Thiel, C, Lübbehusen, J, Dorland, B, de Koning, T, von Figura, K, Lehle, L, Körner, C	Am J Hum Genet	2004
10704531	Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1 Takahashi, T, Honda, R, Nishikawa, Y	Glycobiology	2000