Addition of the first mannose to the N-glycan precursor by ALG1

Stable Identifier
R-HSA-446218
Type
Reaction
Species
Homo sapiens
Compartment
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A mannose is added to the N-glycan precursor via a beta-1,4 linkage. The reaction is catalyzed by ALG1 (Takahashi T et al, 2000). Defects in ALG1 lead to congenital disorder of glycosylation type 1K (CDG1K) (Schwarz et al. 2004; Kranz et al. 2004; Grubenmann et al. 2004).

Literature References
PubMed ID Title Journal Year
14709599 Deficiency of the first mannosylation step in the N-glycosylation pathway causes congenital disorder of glycosylation type Ik

Hennet, T, Mayatepek, E, Frank, CG, Matthijs, G, Grubenmann, CE, Schollen, E, Berger, EG, Hülsmeier, AJ, Aebi, M

Hum Mol Genet 2004
14973782 Congenital disorder of glycosylation type Ik (CDG-Ik): a defect of mannosyltransferase I

Denecke, J, Gudowius, S, Sohlbach, K, Rossi, R, Meinhardt, F, Lehle, L, Jeske, S, Marquardt, T, Kranz, C

Am J Hum Genet 2004
14973778 Deficiency of GDP-Man:GlcNAc2-PP-dolichol mannosyltransferase causes congenital disorder of glycosylation type Ik

Lübbehusen, J, Körner, C, Dorland, B, Lehle, L, von Figura, K, Thiel, C, Schwarz, M, de Koning, T

Am J Hum Genet 2004
10704531 Cloning of the human cDNA which can complement the defect of the yeast mannosyltransferase I-deficient mutant alg 1

Takahashi, T, Nishikawa, Y, Honda, R

Glycobiology 2000
Participants
Participates
Catalyst Activity

chitobiosyldiphosphodolichol beta-mannosyltransferase activity of ALG1 [endoplasmic reticulum membrane]

Orthologous Events
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