Reactome | ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

Stable Identifier

R-HSA-446216

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Addition of the last mannose to the N-glycan precursor by ALG9

ReviewStatus

5/5

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ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1

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The last mannose is added to the N-glycan precursor. This reaction occurs in the ER lumen, uses Dolichyl phosphate D-mannose as the mannose donor, and is catalyzed by ALG9. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L) (Frank CG et al, 2004; Weinstein M et al, 2005). For many years ALG9 was thought to be involved in bipolar affective disorder (Baysal BE et al, 2002), but this hypothesis has been proven wrong (Baysal BE et al, 2006).

Literature References

PubMed ID	Title	Journal	Year
12030331	A mannosyltransferase gene at 11q23 is disrupted by a translocation breakpoint that co-segregates with bipolar affective disorder in a small family Baysal, BE, Badner, JA, Corona, W, Nimgaonkar, VL, Ferrell, RE, Detera-Wadleigh, SD, Willett-Brozick, JE	Neurogenetics	2002
15148656	Identification and functional analysis of a defect in the human ALG9 gene: definition of congenital disorder of glycosylation type IL Hennet, T, Eyaid, W, Frank, CG, Grubenmann, CE, Berger, EG, Aebi, M	Am J Hum Genet	2004
16859551	Common variations in ALG9 are not associated with bipolar I disorder: a family-based study Bacanu, SA, Baysal, BE, Detera-Wadleigh, S, Nimgaonkar, VL, Willett-Brozick, JE	Behav Brain Funct	2006
15945070	CDG-IL: an infant with a novel mutation in the ALG9 gene and additional phenotypic features Hennet, T, Clarke, JT, Frank, CG, Seargeant, L, Matthijs, G, Neupert, C, Grubenmann, CE, Weinstein, M, Poplawski, N, Schollen, E, Griffiths, A, Aebi, M	Am J Med Genet A	2005