Reactome | Flipping of dolichyl-phosphate-glucose into the ER lumen

Flipping of dolichyl-phosphate-glucose into the ER lumen

Stable Identifier

R-HSA-446211

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytoplasmic side of endoplasmic reticulum membrane, lumenal side of endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)

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Flipping of dolichyl-phosphate-glucose into the ER lumen

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Dolichyl-phosphate-glucose is flipped toward the luminal side of the ER membrane (Imbach T et al, 1999). The exact mechanism and proteins involved in this step are not clear yet, but it is known that it must be carried out by a different flippase than the one that catalyzes the flipping of the N-glycan precursor (Sanyal S et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
18597486	Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum Sanyal, S, Frank, CG, Menon, AK	Biochemistry	2008
10359825	A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic Imbach, T, Burda, P, Kuhnert, P, Wevers, RA, Aebi, M, Berger, EG, Hennet, T	Proc Natl Acad Sci U S A	1999