Reactome | Flipping of dolichyl-phosphate-glucose into the ER lumen

Flipping of dolichyl-phosphate-glucose into the ER lumen

Stable Identifier

R-HSA-446211

Type

Reaction [transition]

Species

Homo sapiens

Compartment

integral component of cytoplasmic side of endoplasmic reticulum membrane, integral component of lumenal side of endoplasmic reticulum membrane

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Synthesis of dolichyl-phosphate-glucose (Homo sapiens)
        
        Flipping of dolichyl-phosphate-glucose into the ER lumen (Homo sapiens)

General

SBML | | PDF

SVG | | PPTX | SBGN

Flipping of dolichyl-phosphate-glucose into the ER lumen

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Dolichyl-phosphate-glucose is flipped toward the luminal side of the ER membrane (Imbach T et al, 1999). The exact mechanism and proteins involved in this step are not clear yet, but it is known that it must be carried out by a different flippase than the one that catalyzes the flipping of the N-glycan precursor (Sanyal S et al, 2008).

Literature References

PubMed ID	Title	Journal	Year
10359825	A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic Imbach, T, Burda, P, Kuhnert, P, Wevers, RA, Aebi, M, Berger, EG, Hennet, T	Proc Natl Acad Sci U S A	1999
18597486	Distinct flippases translocate glycerophospholipids and oligosaccharide diphosphate dolichols across the endoplasmic reticulum Sanyal, S, Frank, CG, Menon, AK	Biochemistry	2008