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Synthesis of UDP-N-acetyl-glucosamine
Stable Identifier
R-HSA-446210
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
General
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UDP-acetylglucosamine acts as a donor for the first two steps of the N-glycan precursor biosynthesis pathway, and is later used as a substrate for further modifications after the precursor has been attached to the protein. It is synthesized from fructose 6-phosphate, glutamine, acetyl-CoA, and UTP in four steps.
Participants
Events
RENBP isomerises ManNAc, ManNGc to GlcNAc, GlcNGc
(Homo sapiens)
NAGK dimer phosphorylates GlcNAc, GlcNGc to GlcNAc-6-P, GlcNGc-6-P
(Homo sapiens)
AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA
(Homo sapiens)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P
(Homo sapiens)
Acetylation of glucosamine 6-phosphate to GlcNAc6P
(Homo sapiens)
Isomerization of GlcNAc6P to GlcNAc1P
(Homo sapiens)
GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine
(Homo sapiens)
Participates
as an event of
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Event Information
Go Biological Process
UDP-N-acetylglucosamine biosynthetic process (0006048)
Orthologous Events
Synthesis of UDP-N-acetyl-glucosamine (Bos taurus)
Synthesis of UDP-N-acetyl-glucosamine (Caenorhabditis elegans)
Synthesis of UDP-N-acetyl-glucosamine (Canis familiaris)
Synthesis of UDP-N-acetyl-glucosamine (Danio rerio)
Synthesis of UDP-N-acetyl-glucosamine (Dictyostelium discoideum)
Synthesis of UDP-N-acetyl-glucosamine (Drosophila melanogaster)
Synthesis of UDP-N-acetyl-glucosamine (Gallus gallus)
Synthesis of UDP-N-acetyl-glucosamine (Mus musculus)
Synthesis of UDP-N-acetyl-glucosamine (Plasmodium falciparum)
Synthesis of UDP-N-acetyl-glucosamine (Rattus norvegicus)
Synthesis of UDP-N-acetyl-glucosamine (Saccharomyces cerevisiae)
Synthesis of UDP-N-acetyl-glucosamine (Schizosaccharomyces pombe)
Synthesis of UDP-N-acetyl-glucosamine (Sus scrofa)
Synthesis of UDP-N-acetyl-glucosamine (Xenopus tropicalis)
Authored
Dall'Olio, GM (2009-11-10)
Reviewed
Gagneux, P (2010-04-16)
Created
Jassal, B (2009-11-10)
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