Addition of a second mannose to the N-glycan precursor by ALG2

Stable Identifier
R-HSA-446208
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
ReviewStatus
5/5
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Addition of a second mannose to the N-glycan precursor by ALG2
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A second mannose is added to the N-glycan precursor via an alpha-1,3 linkage. The reaction is catalyzed by the mannosyltransferase ALG2. This is a bifunctional enzyme with both alpha 1,3- and alpha 1,6-mannosyltransferase activities. In humans, only the alpha 1,3 activity used in this reaction has been elucidated (Thiel et al. 2003). Defects in ALG2 are the cause of ALG2-CDG (CDG-1i; MIM:607906) (Thiel et al. 2003).
Literature References
PubMed ID Title Journal Year
12684507 A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis

Thiel, C, Schwarz, M, Peng, J, Grzmil, M, Hasilik, M, Braulke, T, Kohlschütter, A, von Figura, K, Lehle, L, Körner, C

J Biol Chem 2003
Participants
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Output
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as an event of
Catalyst Activity

alpha-1,3-mannosyltransferase activity of ALG2 [endoplasmic reticulum membrane]

Physical Entity
ALG2 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
alpha-1,3-mannosyltransferase activity (GO:0000033)
Orthologous Events
Addition of a second mannose to the N-glycan precursor by ALG2 (Bos taurus)
Addition of a second mannose to the N-glycan precursor by ALG2 (Caenorhabditis elegans)
Addition of a second mannose to the N-glycan precursor by ALG2 (Canis familiaris)
Addition of a second mannose to the N-glycan precursor by ALG2 (Dictyostelium discoideum)
Addition of a second mannose to the N-glycan precursor by ALG2 (Drosophila melanogaster)
Addition of a second mannose to the N-glycan precursor by ALG2 (Gallus gallus)
Addition of a second mannose to the N-glycan precursor by ALG2 (Mus musculus)
Addition of a second mannose to the N-glycan precursor by ALG2 (Rattus norvegicus)
Addition of a second mannose to the N-glycan precursor by ALG2 (Saccharomyces cerevisiae)
Addition of a second mannose to the N-glycan precursor by ALG2 (Schizosaccharomyces pombe)
Addition of a second mannose to the N-glycan precursor by ALG2 (Sus scrofa)
Addition of a second mannose to the N-glycan precursor by ALG2 (Xenopus tropicalis)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
Jassal, B  (2009-11-10)
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