ALG11 transfers the fourth and fifth Man to the N-glycan precursor

Stable Identifier
R-HSA-446187
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11
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ALG11 transfers the fourth and fifth Man to the N-glycan precursor
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A fourth mannose is added to the N-glycan precursor by ALG11. The addition of the fifth mannose, also by ALG11, is the last step occurring on the cytosolic side of the ER membrane (Cipollo JF et al, 2001). Both these reactions are alpha1,2 mannose additions.

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Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
alpha-1,2-mannosyltransferase activity of ALG11 [endoplasmic reticulum membrane]
Physical Entity
ALG11 [endoplasmic reticulum membrane]
Activity
alpha-1,2-mannosyltransferase activity (0000026)
Inferred From
Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11 (Saccharomyces cerevisiae)
Authored
Dall'Olio, GM  (2009-11-10)
Reviewed
Gagneux, P  (2010-04-16)
Created
Jassal, B  (2009-11-10)