Reactome | ALG11 transfers the fourth and fifth Man to the N-glycan precursor

ALG11 transfers the fourth and fifth Man to the N-glycan precursor

Stable Identifier

R-HSA-446187

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Addition of a fourth and fifth mannose to the N-glycan precursor by ALG11

ReviewStatus

5/5

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ALG11 transfers the fourth and fifth Man to the N-glycan precursor

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A fourth mannose is added to the N-glycan precursor by ALG11. The addition of the fifth mannose, also by ALG11, is the last step occurring on the cytosolic side of the ER membrane (Cipollo JF et al, 2001). Both these reactions are alpha1,2 mannose additions.

Literature References

PubMed ID	Title	Journal	Year
11278778	The yeast ALG11 gene specifies addition of the terminal alpha 1,2-Man to the Man5GlcNAc2-PP-dolichol N-glycosylation intermediate formed on the cytosolic side of the endoplasmic reticulum Cipollo, JF, Trimble, RB, Chi, JH, Yan, Q, Dean, N	J Biol Chem	2001

Participants

Input

Output

Participates

as an event of

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)

Catalyst Activity

alpha-1,2-mannosyltransferase activity of ALG11 [endoplasmic reticulum membrane]

Physical Entity

ALG11 [endoplasmic reticulum membrane] (Homo sapiens)

Activity

alpha-1,2-mannosyltransferase activity (GO:0000026)

Inferred From

Addition of the fourth and fifth mannose to the N-glycan precursor skeleton by Alg11 (Saccharomyces cerevisiae)

Authored

Dall'Olio, GM (2009-11-10)

Reviewed

Gagneux, P (2010-04-16)

Created

Jassal, B (2009-11-10)

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