Interleukin-1 receptor type 2 binds Interleukin 1

Stable Identifier
R-HSA-446130
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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Interleukin-1 receptor type 2 binds Interleukin 1
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Interleukin-1 receptor type 2 (IL1R2) binds Interleukin-1 but does not participate in any signaling processes. IL1R2 is thought to be a decoy receptor, removing or neutralizing Interleukin-1 that could otherwise stimulate the type 1 receptor.
Literature References
PubMed ID Title Journal Year
1833184 A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

Brunton, LL, Lupton, SD, Grubin, CE, Mosley, B, Jenkins, NA, McMahan, CJ, Slack, JL, Brannan, CI, Wignall, JM, Cosman, D

EMBO J. 1991
8332913 Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

Mantovani, A, Colotta, F, Polentarutti, N, Re, F, Bertini, R, Dower, SK, Giri, JG, Muzio, M, Sims, JE, Sironi, M

Science 1993
Participants
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Output
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Orthologous Events
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Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)
Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)
Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)
Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2009-11-09)
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