Interleukin-1 receptor type 2 binds Interleukin 1

Stable Identifier
R-HSA-446130
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Interleukin-1 receptor type 2 (IL1R2) binds Interleukin-1 but does not participate in any signaling processes. IL1R2 is thought to be a decoy receptor, removing or neutralizing Interleukin-1 that could otherwise stimulate the type 1 receptor.

Literature References
PubMed ID Title Journal Year
8332913 Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

Colotta, F, Re, F, Muzio, M, Bertini, R, Polentarutti, N, Sironi, M, Giri, JG, Dower, SK, Sims, JE, Mantovani, A

Science 1993
1833184 A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

McMahan, CJ, Slack, JL, Mosley, B, Cosman, D, Lupton, SD, Brunton, LL, Grubin, CE, Wignall, JM, Jenkins, NA, Brannan, CI

EMBO J. 1991
Participants
Participant Of
Orthologous Events
Authored
Reviewed