Interleukin-1 receptor type 2 binds Interleukin 1

Stable Identifier
R-HSA-446130
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
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Summation

Interleukin-1 receptor type 2 (IL1R2) binds Interleukin-1 but does not participate in any signaling processes. IL1R2 is thought to be a decoy receptor, removing or neutralizing Interleukin-1 that could otherwise stimulate the type 1 receptor.

Literature References
PubMed ID Title Journal Year
8332913 Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4

Colotta, F, Re, F, Muzio, M, Bertini, R, Polentarutti, N, Sironi, M, Giri, JG, Dower, SK, Sims, JE, Mantovani, A

Science 1993
1833184 A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types

McMahan, CJ, Slack, JL, Mosley, B, Cosman, D, Lupton, SD, Brunton, LL, Grubin, CE, Wignall, JM, Jenkins, NA, Brannan, CI

EMBO J. 1991
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
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Interleukin-1 receptor type 2 binds Interleukin 1 (Danio rerio)
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Interleukin-1 receptor type 2 binds Interleukin 1 (Mus musculus)
Interleukin-1 receptor type 2 binds Interleukin 1 (Rattus norvegicus)
Interleukin-1 receptor type 2 binds Interleukin 1 (Sus scrofa)
Interleukin-1 receptor type 2 binds Interleukin 1 (Taeniopygia guttata)
Interleukin-1 receptor type 2 binds Interleukin 1 (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Jupe, S  (2009-11-09)