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Type I hemidesmosome assembly
Stable Identifier
R-HSA-446107
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Type I hemidesmosome assembly (Homo sapiens)
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Hemidesmosomes (HDs) are specialized multiprotein junctional complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix and play a critical role in the maintenance of tissue structure and integrity (reviewed in Litjens et al., 2006). HDs mediate adhesion of epithelial cells to the underlying basement membrane in stratified squamous, transitional and pseudostratified epithelia (Jones et al., 1994 ; Borradori and Sonnenberg, 1996). Classical Type I HDs are found in stratified and pseudo-stratified epithelia, such as the skin, and contain a6b4, plectin, tetraspanin CD151 and the bullous pemphigoid (BP) antigens BP180 and BP230 (reviewed in Litjens et al., 2006). While HDs function in promoting stable adhesion, they are highly dynamic structures that are able to disassemble quickly, for example, during cell division, differentiation, or migration (see Margadant et al, 2008).
Literature References
PubMed ID
Title
Journal
Year
16757171
Current insights into the formation and breakdown of hemidesmosomes
Litjens, SH
,
Sonnenberg, A
,
de Pereda, JM
Trends Cell Biol
2006
Participants
Events
Interaction of Plectin with Integrin beta 4
(Homo sapiens)
BP180 interacts intracellularly with plectin and integrin beta4
(Homo sapiens)
BP180 interacts extracellularly with Laminin 332
(Homo sapiens)
BP230 is recruited to the hemidesmosome
(Homo sapiens)
BP230 interacts with keretin K5/K14
(Homo sapiens)
CD151 interacts with BP180 and the integrin alpha 6 subunit
(Homo sapiens)
Participates
as an event of
Cell junction organization (Homo sapiens)
Event Information
Go Biological Process
hemidesmosome assembly (0031581)
Orthologous Events
Type I hemidesmosome assembly (Bos taurus)
Type I hemidesmosome assembly (Canis familiaris)
Type I hemidesmosome assembly (Mus musculus)
Type I hemidesmosome assembly (Rattus norvegicus)
Type I hemidesmosome assembly (Sus scrofa)
Authored
Matthews, L (2009-11-04)
Reviewed
Sonnenberg, A (2009-11-15)
Created
Matthews, L (2009-11-09)
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