Reactome | MYLK(1-1914) [cytosol]

MYLK(1-1914) [cytosol]

Stable Identifier

R-HSA-445807

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin light chain kinase, smooth muscle, MYLK, MYLK_HUMAN

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External Reference Information

External Reference

UniProt:Q15746 MYLK

Gene Names

MYLK, MLCK, MLCK1, MYLK1

Chain

initiator methionine:, initiator methionine:, chain:1-1914, chain:1-1910

Reference Genes

BioGPS Gene:4638 MYLK

COSMIC (genes):MYLK MYLK

CTD Gene:4638 MYLK

dbSNP Gene:4638 MYLK

ENSEMBL:ENSG00000065534.20 MYLK

HGNC:7590 MYLK

KEGG Gene (Homo sapiens):4638 MYLK

Monarch:4638 MYLK

NCBI Gene:4638 MYLK

OMIM:600922 MYLK

UCSC:Q15746 MYLK

Reference Transcript

Other Identifiers

0004610402

11721837_a_at

11727361_a_at

11757621_a_at

1569956_PM_at

1569956_at

16958251

202555_PM_s_at

202555_s_at

224823_PM_at

224823_at

2640092

2683093

2683095

2683103

2692442

2692444

2692446

2692448

2692449

2692450

2692451

2692452

2692455

2692457

2692458

2692459

2692460

2692461

2692462

2692463

2692464

2692465

2692467

2692468

2692469

2692474

2692475

2692476

2692478

2692483

2692484

2692485

2692487

2692489

2692494

2692495

2692498

2692499

2692500

2692501

2692503

2692509

2692510

2692511

2692515

2692516

2692524

2692525

2692526

2692529

2692530

2692531

2692532

2692536

2692537

2692538

2692540

2692551

2692559

2692560

2692561

2692566

2692569

2692570

32847_at

46276_at

4638

8090098

91006_at

A_23_P143817

A_24_P319923

GE62311

GE81581

GO:0000166

GO:0001725

GO:0003012

GO:0003779

GO:0004672

GO:0004674

GO:0004687

GO:0005515

GO:0005516

GO:0005524

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0006939

GO:0008092

GO:0014820

GO:0015629

GO:0016301

GO:0016310

GO:0016740

GO:0030027

GO:0030335

GO:0032060

GO:0032154

GO:0036211

GO:0042060

GO:0042995

GO:0043226

GO:0046872

GO:0048856

GO:0048870

GO:0051928

GO:0060414

GO:0071476

GO:0090303

GO:0140096

HMNXSV003000993

Hs.288965.0.S1_3p_at

Hs2.382024.1.S1_3p_at

ILMN_1691476

ILMN_2364768

PH_hs_0026578

TC03001713.hg

TC03003055.hg

TC03003056.hg

TC03003057.hg

U48959_at

g5174600_3p_a_at

Participates

as an input of

as a component of

MYLK:Ca2+:CALM1 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S1208,S1759-MYLK(1-1914) [cytosol]

Inferred To

MYLK(1-1914) [cytosol] (Bos taurus)

MYLK(1-1914) [cytosol] (Canis familiaris)

MYLK(1-1914) [cytosol] (Danio rerio)

MYLK(1-1914) [cytosol] (Gallus gallus)

MYLK(1-1914) [cytosol] (Mus musculus)

MYLK(1-1914) [cytosol] (Rattus norvegicus)

MYLK(1-1914) [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_016861961.1, NP_444259.1, XP_011511162.1, NP_444255.3, XP_016861960.1, XP_016861962.1, NP_444260.1, NP_444253.3, XP_016861958.1, NP_444256.3, NP_001308238.1, NP_444254.3

Guide to Pharmacology - Targets

1552

OpenTargets

ENSG00000065534

HPA

ENSG00000065534-MYLK

GeneCards

Q15746

Ensembl

ENST00000583087, ENST00000346322, ENSP00000462118, ENSP00000353452, ENST00000578202, ENSP00000354004, ENSP00000320622, ENSG00000065534, ENSP00000463691, ENST00000360772, ENSP00000428967, ENST00000360304, ENST00000418370

ZINC target

Q15746

PRO

Q15746

Pharos - Targets

Q15746

Orphanet

19503

HMDB Protein

HMDBP01417

PDB

2K0F, 2CQV, 5JQA, 6C6M, 5JTH, 2YR3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HD26 GOPC	3	GOPC [lysosomal membrane] (R-HSA-5627281) GOPC [plasma membrane] (R-HSA-5626572) GOPC [Golgi-associated vesicle membrane] (R-HSA-5627067)	0.556	3