Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ACTG2 [cytosol]
Stable Identifier
R-HSA-445783
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Actin, gamma-enteric smooth muscle, ACTH_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Regulation of Homotypic Cell-Cell Adhesion (Homo sapiens)
Regulation of Expression and Function of Type I Classical Cadherins (Homo sapiens)
Regulation of CDH1 Expression and Function (Homo sapiens)
Regulation of CDH1 Function (Homo sapiens)
CDH1 forms homotypic trans-dimers (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Homotypic CDH1 trans-dimer cluster [plasma membrane] (Homo sapiens)
Homotypic CDH1 trans-dimer [plasma membrane] (Homo sapiens)
Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
trans-Man,Man9GlucNAc2,p-3S-CDH1:CTNNB1,JUP:CTNNA1:CTNND1:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
trans-homotypic CDH1 cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
CDH1-associated CTNNA1 binds F-actin (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
CDH1-associated CTNNA1 binds VCL (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin:VCL [plasma membrane] (Homo sapiens)
Homotypic CDH1 cis-cluster:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
DGC:laminin complex binds F-actin (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
(ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
ACTA2, ACTG2 [cytosol] (Homo sapiens)
ACTG2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63267 ACTG2
Gene Names
ACTG2, ACTA3, ACTL3, ACTSG
Chain
initiator methionine:1, chain:2-376, chain:3-376
Reference Genes
BioGPS Gene:72 ACTG2
COSMIC (genes):ACTG2 ACTG2
CTD Gene:72 ACTG2
dbSNP Gene:72 ACTG2
ENSEMBL:ENSG00000163017 ACTG2
HGNC:145 ACTG2
KEGG:hsa:72 ACTG2
Monarch:72 ACTG2
NCBI Gene:72 ACTG2
OMIM:102545 ACTG2
UCSC:P63267 ACTG2
Reference Transcript
RefSeq:NM_001199893.2 ACTG2
RefSeq:NM_001615.4 ACTG2
Other Identifiers
11715793_a_at
11715794_x_at
11748016_a_at
1197_at
16881594
202274_PM_at
202274_at
2489008
2489010
2489012
2489013
2489014
2489015
2489016
2489017
2489018
2489019
2489020
2489021
2489022
2489025
2489026
2489029
2489030
2489031
69512_at
72
8042788
A_14_P127205
A_23_P39955
A_33_P3418541
D00654_at
GO:0000166
GO:0005524
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0010628
GO:0015629
GO:0016787
GO:0030027
GO:0030175
GO:0032982
GO:0044297
GO:0045471
GO:0070062
GO:0071354
GO:0071944
GO:0072562
GO:0090131
GO:1905641
HMNXSV003011213
HMNXSV003029342
ILMN_1795325
PH_hs_0030035
TC02000448.hg
g11038625_3p_at
Participates
as a member of
ACTA2, ACTG2 [cytosol] (Homo sapiens)
Inferred To
acta2 [cytosol]
(Danio rerio)
acta2 [cytosol]
(Xenopus tropicalis)
act-5 [cytosol]
(Caenorhabditis elegans)
Arp53D [cytosol]
(Drosophila melanogaster)
Actg2 [cytosol]
(Mus musculus)
Actg2 [cytosol]
(Rattus norvegicus)
ACTG2 [cytosol]
(Bos taurus)
ACTG2 [cytosol]
(Canis familiaris)
ACTG2 [cytosol]
(Gallus gallus)
ACTG2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001186822.1
,
NP_001606.1
ENSEMBL
ENSG00000163017
,
ENST00000345517
,
ENSP00000386929
,
ENST00000409731
,
ENSP00000295137
,
ENST00000409624
,
ENSP00000386857
OpenTargets
ENSG00000163017
GeneCards
ACTG2
HPA
ENSG00000163017-ACTG2
PRO
P63267
Pharos - Targets
P63267
GlyGen
P63267
Orphanet
ACTG2
PDB
8V30
,
8V2O
,
8V2Z
,
6JAT
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![ACTG2 [cytosol] icon](/icon/R-ICO-012386.svg){kind=icon}
