Reactome | ACTG2 [cytosol]

ACTG2 [cytosol]

Stable Identifier

R-HSA-445783

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Actin, gamma-enteric smooth muscle, ACTH_HUMAN

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Locations in the PathwayBrowser

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Extracellular matrix organization (Homo sapiens)

- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
    - DGC complex binds AGRN and HSPG2 (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
      - DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
        
        DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
    - DGC:laminin complex binds F-actin (Homo sapiens)
      - DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
        
        F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
      - F-actin (all) [cytosol] (Homo sapiens)
        
        actins:ATP [cytosol] (Homo sapiens)
        
        (ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - F-actin (ACTA2,ACTG2:ATP) [cytosol] (Homo sapiens)
        
        (ACTA2,ACTG2):ATP [cytosol] (Homo sapiens)
        
        ACTA2, ACTG2 [cytosol] (Homo sapiens)
        
        ACTG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63267 ACTG2

Gene Names

ACTG2, ACTA3, ACTL3, ACTSG

Chain

initiator methionine:, chain:2-376, chain:3-376

Reference Genes

BioGPS Gene:72 ACTG2

COSMIC (genes):ACTG2 ACTG2

CTD Gene:72 ACTG2

dbSNP Gene:72 ACTG2

ENSEMBL:ENSG00000163017 ACTG2

HGNC:145 ACTG2

Monarch:72 ACTG2

NCBI Gene:72 ACTG2

OMIM:102545 ACTG2

UCSC:P63267 ACTG2

Reference Transcript

Other Identifiers

11715793_a_at

11715794_x_at

11748016_a_at

1197_at

16881594

202274_PM_at

202274_at

2489008

2489010

2489013

2489014

2489015

2489016

2489017

2489018

2489019

2489020

2489021

2489022

2489025

2489026

2489029

2489030

2489031

8042788

A_14_P127205

A_23_P39955

A_33_P3418541

D00654_at

GO:0003824

GO:0005524

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0010628

GO:0016787

GO:0030027

GO:0030175

GO:0032982

GO:0043226

GO:0044297

GO:0070062

GO:0071944

GO:0072562

GO:0090131

HMNXSV003011213

HMNXSV003029342

ILMN_1795325

PH_hs_0030035

TC02000448.hg

g11038625_3p_at

Participates

as a member of

ACTA2, ACTG2 [cytosol] (Homo sapiens)

Inferred To

Act88F [cytosol] (Drosophila melanogaster)

Arp53D [cytosol] (Drosophila melanogaster)

Act57B [cytosol] (Drosophila melanogaster)

Act87E [cytosol] (Drosophila melanogaster)

Actg2 [cytosol] (Mus musculus)

Actg2 [cytosol] (Rattus norvegicus)

Homologues of ACTG2 [cytosol] (Drosophila melanogaster)

ACTG2 [cytosol] (Bos taurus)

ACTG2 [cytosol] (Canis familiaris)

ACTG2 [cytosol] (Gallus gallus)

ACTG2 [cytosol] (Sus scrofa)

Act79B [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENSP00000295137, ENSP00000386929, ENST00000409731, ENST00000345517, ENST00000409624, ENSP00000386857

OpenTargets

ENSG00000163017

HPA

ENSG00000163017-ACTG2

PRO

P63267

Pharos - Targets

P63267

GlyGen

P63267

Orphanet

ACTG2

PDB

8V30, 6JAT, 8V2O, 8V2Z

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