IL1 receptor antagonist protein binds Interleukin 1 receptors

Stable Identifier
R-HSA-445757
Type
Reaction [binding]
Species
Homo sapiens
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The interleukin 1 receptor antagonist protein (ILRAP or IL1RN) is a member of the IL1 family that binds to IL1R1 (and with much lower affinity IL1R2) but does not elicit a signaling response. By competing with IL1 for IL1R1 binding ILRAP acts as a natural antagonist, inhibiting the biological actions of both agonist forms of IL1 (IL1 alpha and IL1 beta).

Literature References
PubMed ID Title Journal Year
1828071 Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction

Dripps, DJ, Brandhuber, BJ, Thompson, RC, Eisenberg, SP

J Biol Chem 1991
2139180 Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

Carter, DB, Deibel MR, Jr, Dunn, CJ, Tomich, CS, Laborde, AL, Slightom, JL, Berger, AE, Bienkowski, MJ, Sun, FF, McEwan, RN

Nature 1990
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