Reactome | IL1 receptor antagonist protein binds Interleukin 1 receptors

IL1 receptor antagonist protein binds Interleukin 1 receptors

Stable Identifier

R-HSA-445757

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

IL1 receptor antagonist protein binds Interleukin 1 receptors

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The interleukin 1 receptor antagonist protein (ILRAP or IL1RN) is a member of the IL1 family that binds to IL1R1 (and with much lower affinity IL1R2) but does not elicit a signaling response. By competing with IL1 for IL1R1 binding ILRAP acts as a natural antagonist, inhibiting the biological actions of both agonist forms of IL1 (IL1 alpha and IL1 beta).

Literature References

PubMed ID	Title	Journal	Year
2139180	Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein Bienkowski, MJ, Deibel MR, Jr, Laborde, AL, McEwan, RN, Slightom, JL, Tomich, CS, Dunn, CJ, Carter, DB, Sun, FF, Berger, AE	Nature	1990
1828071	Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction Eisenberg, SP, Dripps, DJ, Brandhuber, BJ, Thompson, RC	J Biol Chem	1991