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Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform
Stable Identifier
R-HSA-445752
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Homo sapiens)
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Interleukin receptor 1 type 1 when bound to interleukin 1 binds interleukin 1 receptor accessory protein, essential for eliciting a signaling cascade.
Literature References
PubMed ID
Title
Journal
Year
9371760
Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein
Cao, Z
,
Gao, X
,
Li, S
,
Huang, J
Proc Natl Acad Sci U S A
1997
Participants
Input
IL1B,Myr82K-Myr83K-IL1A:IL1R1 [plasma membrane]
(Homo sapiens)
IL1RAP-1 [plasma membrane]
(Homo sapiens)
Output
IL1R1:IL1:IL1RAP [plasma membrane]
(Homo sapiens)
Participates
as an event of
Interleukin-1 signaling (Homo sapiens)
Orthologous Events
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Bos taurus)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Canis familiaris)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Gallus gallus)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Mus musculus)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Rattus norvegicus)
Interleukin-1 receptor type 1: Interleukin 1 binds Interleukin-1 receptor accessory protein, membrane associated isoform (Xenopus tropicalis)
Authored
Ray, KP (2010-05-17)
Reviewed
Pinteaux, E (2010-05-17)
Created
Jupe, S (2009-11-05)
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