Reactome | Aquaporin-3 passively transports water out of cell

Aquaporin-3 passively transports water out of cell

Stable Identifier

R-HSA-445714

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Aquaporin-3 passively transports water out of cell

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Aquaporin-3 (AQP3) passively transports water and glycerol across the plasma membrane according to the osmotic gradient. AQP3 is expressed in airway epithelia, secretory glands, skin, the collecting ducts of the kidney, and the basolateral surface of intestinal epithelium..

Literature References

PubMed ID	Title	Journal	Year
9374640	Aquaporins in complex tissues. II. Subcellular distribution in respiratory and glandular tissues of rat Christensen, BM, Nielsen, S, Agre, P, King, LS	Am J Physiol	1997
18678926	Compartmentalization of aquaporins in the human intestine Isokpehi, R, Rajnarayanan, RV, Cohly, HH	Int J Environ Res Public Health	2008
7503232	Aquaporin-3 water channel localization and regulation in rat kidney Marples, D, Echevarria, M, Ecelbarger, CA, Terris, J, Knepper, MA, Frindt, G, Nielsen, S	Am J Physiol	1995
7526388	Cloning and expression of AQP3, a water channel from the medullary collecting duct of rat kidney Echevarria, M, Tate, SS, Frindt, G, Windhager, EE	Proc Natl Acad Sci U S A	1994
9374639	Aquaporins in complex tissues. I. Developmental patterns in respiratory and glandular tissues of rat Nielsen, S, Agre, P, King, LS	Am J Physiol	1997
7538665	Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes Turck, CW, Verkman, AS, Frigeri, A, Gropper, MA	Proc Natl Acad Sci U S A	1995
8063828	Cloning of a water channel homolog expressed in brain meningeal cells and kidney collecting duct that functions as a stilbene-sensitive glycerol transporter Ma, T, Verkman, AS, Frigeri, A, Hasegawa, H	J Biol Chem	1994
9369468	Mercury-sensitive residues and pore site in AQP3 water channel Marumo, F, Gu, Y, Kuwahara, M, Ishibashi, K, Sasaki, S	Biochemistry	1997
15703994	Distribution of AQP2 and AQP3 water channels in human tissue microarrays Marples, D, Wray, S, Mobasheri, A	J Mol Histol	2005