Reactome | p-T287-CAMK2G [cytosol]

p-T287-CAMK2G [cytosol]

Stable Identifier

R-HSA-445369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ca/calmodulin dependent proetin kinase II gamma subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Oncogenic MAPK signaling (Homo sapiens)
    - Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
      - RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
    - Signaling by BRAF and RAF1 fusions (Homo sapiens)
      - BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
    - Signaling by RAF1 mutants (Homo sapiens)
      - Phosphorylation of RAF1 mutants (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
    - Signaling by RAS mutants (Homo sapiens)
      - Signaling downstream of RAS mutants (Homo sapiens)
        
        RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
    - Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
      - RAF is phosphorylated downstream of moderate kinase activity BRAF mutants (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Interferon Signaling (Homo sapiens)
    - Interferon gamma signaling (Homo sapiens)
      - Phosphorylation of STAT1 at Ser727 (Homo sapiens)
        
        CaMKII and PKC-delta [cytosol] (Homo sapiens)
        
        CaMKII [cytosol] (Homo sapiens)
        
        CaMKII delta/gamma [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)

Neuronal System (Homo sapiens)

- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - Activation of NMDA receptors and postsynaptic events (Homo sapiens)
      - Negative regulation of NMDA receptor-mediated neuronal transmission (Homo sapiens)
        
        PPM1F dephosphorylates p-T286-CaMKII (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
      - Post NMDA receptor activation events (Homo sapiens)
        
        CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
        
        p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G dodecamer [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        Long-term potentiation (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII binds activated NMDA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        CaMKII phosphorylates AMPA receptor (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
      - Unblocking of NMDA receptors, glutamate binding and activation (Homo sapiens)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Homo sapiens)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - DAG and IP3 signaling (Homo sapiens)
    - CaM pathway (Homo sapiens)
      - Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
        
        p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G dodecamer [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        Phosphorylation of RAF (Homo sapiens)
        
        RAF activating kinases [plasma membrane] (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Opioid Signalling (Homo sapiens)
        
        G-protein mediated events (Homo sapiens)
        
        PLC beta mediated events (Homo sapiens)
        
        Ca-dependent events (Homo sapiens)
        
        CaM pathway (Homo sapiens)
        
        Calmodulin induced events (Homo sapiens)
        
        CaMK IV-mediated phosphorylation of CREB (Homo sapiens)
        
        CaMKII autophosphorylates (Homo sapiens)
        
        p-T286-CaMKII dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T286-CaMKII dodecamer [cytosol] (Homo sapiens)
        
        p-T286-CAMK2A,p-T287-CAMK2B,(p-T287-CAMK2D,p-T287-CAMK2G) [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)
        
        Calmodulin-bound CaMKII-gamma enters the nucleus (Homo sapiens)
        
        p-T287-CAMK2G dodecamer:CALM1:4xCa2+ [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G dodecamer [cytosol] (Homo sapiens)
        
        p-T287-CAMK2G [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13555 CAMK2G

Gene Names

CAMK2G, CAMK, CAMK-II, CAMKG

Chain

chain:1-558

Reference Genes

BioGPS Gene:818 CAMK2G

COSMIC (genes):CAMK2G CAMK2G

CTD Gene:818 CAMK2G

dbSNP Gene:818 CAMK2G

ENSEMBL:ENSG00000148660 CAMK2G

ENSEMBL:ENSG00000148660.22 CAMK2G

HGNC:1463 CAMK2G

KEGG Gene (Homo sapiens):818 CAMK2G

Monarch:818 CAMK2G

NCBI Gene:818 CAMK2G

OMIM:602123 CAMK2G

UCSC:Q13555 CAMK2G

Reference Transcript

Other Identifiers

11717265_a_at

11717266_s_at

11717267_x_at

11717268_a_at

11736354_a_at

11749986_a_at

1559701_PM_s_at

1559701_s_at

16715667

212669_PM_at

212669_at

212757_PM_s_at

212757_s_at

214322_PM_at

214322_at

32104_i_at

32105_f_at

3294848

3294849

3294850

3294851

3294852

3294853

3294855

3294856

3294857

3294858

3294859

3294860

3294861

3294862

3294866

3294867

3294868

3294881

3294883

3294888

3294889

3294892

3294901

3294903

3294906

3294907

3294912

3294913

3294918

3294920

3294923

3294926

3294928

3294933

3294946

3294948

3294949

39388_at

650_s_at

7934477

818

A_23_P46903

A_24_P141332

A_24_P85365

A_33_P3329255

GE59328

GO:0000166

GO:0003012

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0004723

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005954

GO:0006468

GO:0007399

GO:0010975

GO:0014733

GO:0016020

GO:0016301

GO:0016310

GO:0016529

GO:0016740

GO:0016787

GO:0023052

GO:0030073

GO:0030154

GO:0030666

GO:0031410

GO:0033017

GO:0036211

GO:0042802

GO:0042803

GO:0043005

GO:0043226

GO:0048856

GO:0051924

GO:0106310

GO:0140096

HMNXSV003017757

HMNXSV003041836

Hs.12436.0.A1_3p_a_at

Hs.250857.1.A1_3p_at

Hs.250857.2.A1_3p_at

Hs2.406925.1.S1_3p_s_at

ILMN_1795992

ILMN_1809695

ILMN_2359601

L07044_at

PH_hs_0001179

TC10001420.hg

TC10002711.hg

U50360_s_at

p33373

Participates

as a member of

as a component of

p-T287-CAMK2G dodecamer [cytosol] (Homo sapiens)

Other forms of this molecule

p-T287-CAMK2G [plasma membrane]

p-T287-CAMK2G [endocytic vesicle membrane]

p-T287-CAMK2G [nucleoplasm]

CAMK2G [cytosol]

Inferred To

Homologues of p-T287-CAMK2G [cytosol] (Danio rerio)

phospho-p-T287-CAMK2G [cytosol] (Caenorhabditis elegans)

phospho-p-T287-CAMK2G [cytosol] (Canis familiaris)

phospho-p-T287-CAMK2G [cytosol] (Danio rerio)

phospho-p-T287-CAMK2G [cytosol] (Drosophila melanogaster)

phospho-p-T287-CAMK2G [cytosol] (Gallus gallus)

phospho-p-T287-CAMK2G [cytosol] (Mus musculus)

phospho-p-T287-CAMK2G [cytosol] (Rattus norvegicus)

phospho-p-T287-CAMK2G [cytosol] (Sus scrofa)

phospho-p-T287-CAMK2G [cytosol] (Xenopus tropicalis)

phospho-CAMK2G [cytosol] (Bos taurus)

Modified Residues

Name

O-phospho-L-threonine at 287

Coordinate

287

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_751909.1, XP_005270260.1, NP_001307827.1, NP_001213.2, NP_751913.1, NP_001191421.1

ZINC - World Drugs

KCC2G_HUMAN

Guide to Pharmacology - Targets

1557

OpenTargets

ENSG00000148660

ZINC - FDA approved

KCC2G_HUMAN

ZINC - Substances

KCC2G_HUMAN

ZINC - Biogenic

KCC2G_HUMAN

ZINC target

Q13555

PRO

Q13555

PDB

2V7O, 2UX0

ZINC - Investigational

KCC2G_HUMAN

GeneCards

Q13555

HPA

ENSG00000148660-CAMK2G

Ensembl

ENSG00000148660, ENSP00000277853, ENST00000305762, ENSP00000315599, ENST00000322635, ENST00000680035, ENSP00000307082, ENST00000351293, ENSP00000505103

Pharos - Targets

Q13555

ZINC - Predictions - Purchasable

KCC2G_HUMAN

HMDB Protein

HMDBP09421

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.524	2

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