Reactome | UTS2 [extracellular region]

UTS2 [extracellular region]

Stable Identifier

R-HSA-445122

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Urotensin-2, UTS2_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95399 UTS2

Gene Names

UTS2, UNQ525/PRO1068

Chain

signal peptide:1-20, propeptide:21-110, peptide:114-124

Reference Genes

BioGPS Gene:10911 UTS2

COSMIC (genes):UTS2 UTS2

CTD Gene:10911 UTS2

dbSNP Gene:10911 UTS2

ENSEMBL:ENSG00000049247 UTS2

HGNC:12636 UTS2

KEGG:hsa:10911 UTS2

Monarch:10911 UTS2

NCBI Gene:10911 UTS2

OMIM:604097 UTS2

UCSC:O95399 UTS2

Reference Transcript

Other Identifiers

10911

11734605_a_at

16681278

220784_PM_s_at

220784_s_at

220785_PM_at

220785_at

2395124

2395125

2395126

2395127

2395128

2395129

2395130

2395131

2395132

2395133

2395134

7912136

A_23_P63343

A_24_P45620

GE80745

GO:0003012

GO:0003013

GO:0005102

GO:0005179

GO:0005576

GO:0005615

GO:0006936

GO:0007165

GO:0007268

GO:0008217

GO:0023052

GO:0045202

GO:0048018

GO:0097746

GO:0098772

HMNXSV003004750

HMNXSV003054955

ILMN_1671818

ILMN_1732198

ILMN_1775780

ILMN_2236625

PH_hs_0009844

TC01002162.hg

g12056478_3p_a_at

Participates

as a member of

UTS2,UTS2B [extracellular region] (Homo sapiens)

Inferred To

Uts2 [extracellular region] (Mus musculus)

Uts2 [extracellular region] (Rattus norvegicus)

UTS2 [extracellular region] (Bos taurus)

UTS2 [extracellular region] (Canis familiaris)

UTS2 [extracellular region] (Gallus gallus)

UTS2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_068835.1, XP_011538840.1, NP_006777.1, XP_011538839.1

ENSEMBL

ENST00000054668, ENSP00000054668, ENSP00000355163, ENST00000361696

OpenTargets

ENSG00000049247

HPA

ENSG00000049247-UTS2

ZINC - Substances

UTS2_HUMAN

ZINC target

O95399

PRO

O95399

Pharos - Targets

O95399

GlyGen

O95399

ZINC - Predictions - Purchasable

UTS2_HUMAN

PDB

6HVB, 6HVC