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Go!
SMO [plasma membrane]
Stable Identifier
R-HSA-445121
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Smoothened homolog, SMO_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
BBSome-mediated cargo-targeting to cilium (Homo sapiens)
ARL6:GTP and the BBSome bind ciliary cargo (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
SMO [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
SMO [plasma membrane] (Homo sapiens)
ARL6:GTP and the BBSome target cargo to the primary cilium (Homo sapiens)
ARL6:GTP:BBSome:ciliary cargo [plasma membrane] (Homo sapiens)
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
SMO [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Patched binds Smoothened (Homo sapiens)
PTCH1,PTCH2:SMO [plasma membrane] (Homo sapiens)
SMO [plasma membrane] (Homo sapiens)
SMO [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99835 SMO
Gene Names
SMO, SMOH
Chain
signal peptide:1-27, chain:28-787
Reference Genes
BioGPS Gene:6608 SMO
COSMIC (genes):SMO SMO
CTD Gene:6608 SMO
dbSNP Gene:6608 SMO
ENSEMBL:ENSG00000128602 SMO
HGNC:11119 SMO
KEGG:hsa:6608 SMO
Monarch:6608 SMO
NCBI Gene:6608 SMO
OMIM:601500 SMO
UCSC:Q99835 SMO
Reference Transcript
RefSeq:NM_005631.4 SMO
Other Identifiers
11721795_a_at
11758405_s_at
17051392
218629_PM_at
218629_at
3023352
3023353
3023354
3023355
3023356
3023357
3023358
3023361
3023363
3023364
3023365
3023366
3023368
3023369
3023370
3023371
3023372
3023373
3023374
3023377
3023378
3023379
3023380
3023381
32960_at
49344_at
6608
8136080
A_14_P101701
A_23_P70818
GE54831
GE79505
GO:0000122
GO:0001503
GO:0001570
GO:0001649
GO:0001701
GO:0001708
GO:0001755
GO:0001933
GO:0001942
GO:0001947
GO:0002052
GO:0002053
GO:0003007
GO:0003140
GO:0003323
GO:0004862
GO:0004888
GO:0004930
GO:0005113
GO:0005515
GO:0005737
GO:0005768
GO:0005770
GO:0005783
GO:0005793
GO:0005794
GO:0005814
GO:0005886
GO:0005901
GO:0005929
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0006915
GO:0007166
GO:0007186
GO:0007224
GO:0007368
GO:0007371
GO:0007389
GO:0007405
GO:0007417
GO:0007494
GO:0008142
GO:0008283
GO:0008284
GO:0008289
GO:0009888
GO:0009952
GO:0009953
GO:0010467
GO:0010468
GO:0010628
GO:0010629
GO:0012501
GO:0016020
GO:0021513
GO:0021542
GO:0021696
GO:0021794
GO:0021904
GO:0021953
GO:0021987
GO:0023052
GO:0030154
GO:0030335
GO:0030425
GO:0030666
GO:0030855
GO:0030857
GO:0031069
GO:0031410
GO:0032502
GO:0034236
GO:0034504
GO:0035264
GO:0040018
GO:0042307
GO:0042475
GO:0042995
GO:0043066
GO:0043226
GO:0043231
GO:0043392
GO:0045880
GO:0045892
GO:0045893
GO:0045944
GO:0046622
GO:0048143
GO:0048468
GO:0048565
GO:0048568
GO:0048589
GO:0048741
GO:0048745
GO:0048853
GO:0048856
GO:0048870
GO:0048873
GO:0050673
GO:0050679
GO:0050821
GO:0051451
GO:0051799
GO:0060089
GO:0060170
GO:0060242
GO:0060413
GO:0060644
GO:0060684
GO:0061053
GO:0061113
GO:0070062
GO:0070986
GO:0071397
GO:0071542
GO:0071679
GO:0072285
GO:0090190
GO:0097542
GO:0097731
GO:0098772
GO:0120025
GO:0140311
GO:0140313
GO:1904672
GO:2000826
HMNXSV003006024
ILMN_1782098
PH_hs_0025642
TC07000795.hg
g5032098_3p_s_at
Participates
as a component of
PTCH1,PTCH2:SMO [plasma membrane] (Homo sapiens)
as an input of
Patched binds Smoothened (Homo sapiens)
as a candidate of
BBSome ciliary cargo [plasma membrane] (Homo sapiens)
Other forms of this molecule
pS588, S590, T593, S595, S611, S615, S616-SMO [ciliary membrane]
SMO [endocytic vesicle membrane]
SMO [ciliary tip]
pS588, S590, T593, S595-SMO [ciliary membrane]
SMO [ciliary membrane]
Inferred To
SMO [plasma membrane]
(Bos taurus)
SMO [plasma membrane]
(Canis familiaris)
SMO [plasma membrane]
(Gallus gallus)
SMO [plasma membrane]
(Mus musculus)
SMO [plasma membrane]
(Rattus norvegicus)
SMO [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005622.1
ZINC - World Drugs
SMO_HUMAN
Guide to Pharmacology - Targets
239
OpenTargets
ENSG00000128602
ENSEMBL
ENSP00000249373
,
ENST00000249373
ZINC - FDA approved
SMO_HUMAN
ZINC - Substances
SMO_HUMAN
ZINC - Biogenic
SMO_HUMAN
ZINC target
Q99835
PRO
Q99835
GlyGen
Q99835
PDB
5L7D
,
5V56
,
5V57
,
6XBK
,
6XBJ
,
4O9R
,
6XBL
,
6XBM
,
4JKV
,
7ZI0
,
5L7I
,
4QIM
,
4QIN
,
6OT0
,
4N4W
ZINC - Investigational
SMO_HUMAN
ZINC - Metabolites
SMO_HUMAN
HPA
ENSG00000128602-SMO
Pharos - Targets
Q99835
Orphanet
SMO
ZINC - Predictions - Purchasable
SMO_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59768 GNG2
1
GNG2 [plasma membrane]
(R-HSA-164380)
0.488
2
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