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UTS2R [plasma membrane]
Stable Identifier
R-HSA-445114
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Urotensin II receptor, UR2R_HUMAN, GPR14
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
UTS2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UKP6 UTS2R
Gene Names
UTS2R, GPR14
Chain
chain:1-389
Reference Genes
BioGPS Gene:2837 UTS2R
COSMIC (genes):UTS2R UTS2R
CTD Gene:2837 UTS2R
dbSNP Gene:2837 UTS2R
ENSEMBL:ENSG00000181408 UTS2R
ENSEMBL_homo_sapiens_GENE:ENSG00000181408.5 UTS2R
HGNC:4468 UTS2R
KEGG Gene (Homo sapiens):2837 UTS2R
Monarch:2837 UTS2R
NCBI Gene:2837 UTS2R
OMIM:600896 UTS2R
UCSC:Q9UKP6 UTS2R
Reference Transcript
RefSeq:NM_018949.2 UTS2R
Other Identifiers
11715264_s_at
1553262_3p_a_at
1553262_PM_a_at
1553262_a_at
16839038
2837
3738813
3738819
3738821
3738822
3738823
3738824
3738825
3738826
3738827
3738828
3738829
3738830
3738831
3738832
3738833
68357_at
8010783
ADDON002774.hg
A_23_P146885
GE80620
GO:0001604
GO:0003013
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0007218
GO:0008015
GO:0008217
GO:0016020
GO:0023052
GO:0060089
GO:0097746
HMNXSV003013543
Hs2.192720.1.A1_3p_s_at
ILMN_1747962
PH_hs_0032091
TC17000950.hg
Participates
as an input of
Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
Inferred To
AstA-R2 [plasma membrane]
(Drosophila melanogaster)
npr-14 [plasma membrane]
(Caenorhabditis elegans)
UTS2R [plasma membrane]
(Canis familiaris)
UTS2R [plasma membrane]
(Gallus gallus)
UTS2R [plasma membrane]
(Sus scrofa)
Uts2r [plasma membrane]
(Mus musculus)
Uts2r [plasma membrane]
(Rattus norvegicus)
uts2r [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_061822.1
Guide to Pharmacology - Targets
365
OpenTargets
ENSG00000181408
ZINC - Substances
UR2R_HUMAN
ZINC target
Q9UKP6
PRO
Q9UKP6
PDB
6HVK
HPA
ENSG00000181408-UTS2R
GeneCards
Q9UKP6
Ensembl
ENST00000313135
,
ENSG00000181408
,
ENSP00000323516
Pharos - Targets
Q9UKP6
ZINC - Predictions - Purchasable
UR2R_HUMAN
HMDB Protein
HMDBP08097
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