Urotensin-2 receptor binds urotensin-2 and 2B

Stable Identifier
R-HSA-445113
Type
Reaction [binding]
Species
Homo sapiens
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Urotensin-II (U2) is a vasoactive 'somatostatin-like' cyclic peptide originally isolated from fish spinal cords. It was found to activate GPR14 later renamed Urotensin II receptor (U2R).
U2 is the most potent known vasoconstrictor. A second ligand for U2R, urotensin-related peptide or Urotensin 2B, was identified as an extract from rat brains, and shown to activate rat and human U2R.

Literature References
PubMed ID Title Journal Year
14550283 Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain

Sugo, T, Murakami, Y, Shimomura, Y, Harada, M, Abe, M, Ishibashi, Y, Kitada, C, Miyajima, N, Suzuki, N, Mori, M, Fujino, M

Biochem Biophys Res Commun 2003
10499587 Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14

Ames, RS, Sarau, HM, Chambers, JK, Willette, RN, Aiyar, NV, Romanic, AM, Louden, CS, Foley, JJ, Sauermelch, CF, Coatney, RW, Ao, Z, Disa, J, Holmes, SD, Stadel, JM, Martin, JD, Liu, WS, Glover, GI, Wilson, S, McNulty, DE, Ellis, CE, Elshourbagy, NA, Shabon, U, Trill, JJ, Hay, DW, Ohlstein, EH, Bergsma, DJ, Douglas, SA

Nature 1999
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