Reactome | UTS2B [extracellular region]

UTS2B [extracellular region]

Stable Identifier

R-HSA-445100

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Urotensin-2B, UTS2D, UTS2B_HUMAN

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
        
        Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Urotensin-2 receptor binds urotensin-2 and 2B (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)
        
        UTSR:UTS2,UTS2B [plasma membrane] (Homo sapiens)
        
        UTS2,UTS2B [extracellular region] (Homo sapiens)
        
        UTS2B [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q765I0 UTS2B

Gene Names

UTS2B, URP, UTS2D

Chain

signal peptide:1-28, propeptide:29-109, peptide:112-119

Reference Genes

BioGPS Gene:257313 UTS2B

COSMIC (genes):UTS2B UTS2B

CTD Gene:257313 UTS2B

dbSNP Gene:257313 UTS2B

ENSEMBL:ENSG00000188958 UTS2B

ENSEMBL_homo_sapiens_GENE:ENSG00000188958.10 UTS2B

HGNC:30894 UTS2B

KEGG Gene (Homo sapiens):257313 UTS2B

Monarch:257313 UTS2B

NCBI Gene:257313 UTS2B

OMIM:618134 UTS2B

UCSC:Q765I0 UTS2B

Reference Transcript

Other Identifiers

11737193_at

11737194_at

16962705

243175_PM_at

243175_at

257313

2710768

2710769

2710771

2710773

2710777

2710779

2710780

2710781

2710784

2710786

2710788

2710791

2710793

60180_r_at

8092741

A_32_P225659

GE725991

GO:0001664

GO:0003013

GO:0005179

GO:0005576

GO:0007165

GO:0008217

GO:0023052

GO:0048018

GO:0097746

GO:0098772

HMNXSV003045597

Hs.177653.0.S1_3p_at

ILMN_1812093

ILMN_2180232

PH_hs_0033293

TC03002113.hg

Participates

as a member of

UTS2,UTS2B [extracellular region] (Homo sapiens)

Inferred To

Uts2b [extracellular region] (Mus musculus)

Uts2b [extracellular region] (Rattus norvegicus)

UTS2B [extracellular region] (Bos taurus)

UTS2B [extracellular region] (Canis familiaris)

UTS2B [extracellular region] (Gallus gallus)

UTS2B [extracellular region] (Sus scrofa)

uts2b [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_937795.2, XP_011510933.1

OpenTargets

ENSG00000188958

GeneCards

Q765I0

HPA

ENSG00000188958-UTS2B

Ensembl

ENSG00000188958, ENSP00000340526, ENST00000340524, ENST00000427544, ENSP00000398761

PRO

Q765I0

Pharos - Targets

Q765I0