Phosphorylation of VAV2

Stable Identifier
R-HSA-445085
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of VAV2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
L1 crosslinking leads to the tyrosine phosphorylation and activation of VAV2. Tyr-172 in VAV2 binds to the DBL homology region autoinhibiting its GEF-activity. Tyrosine kinase src may phosphorylate this residue and relieve the autoinhibition.
Literature References
PubMed ID Title Journal Year
15597056 Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling

Schmid, RS, Midkiff, BR, Kedar, VP, Maness, PF

Neuroreport 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of unidentified protein tyrosine kinase [cytosol]

Physical Entity
unidentified protein tyrosine kinase [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
Cite Us!