Phosphorylation of VAV2

Stable Identifier
R-HSA-445085
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Phosphorylation of VAV2
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L1 crosslinking leads to the tyrosine phosphorylation and activation of VAV2. Tyr-172 in VAV2 binds to the DBL homology region autoinhibiting its GEF-activity. Tyrosine kinase src may phosphorylate this residue and relieve the autoinhibition.
Literature References
PubMed ID Title Journal Year
15597056 Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling

Schmid, RS, Midkiff, BR, Maness, PF, Kedar, VP

Neuroreport 2004
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Catalyst Activity

protein tyrosine kinase activity of unidentified protein tyrosine kinase [cytosol]

Physical Entity
unidentified protein tyrosine kinase [cytosol] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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