Reactome | Phosphorylation of L1 by ERK

Phosphorylation of L1 by ERK

Stable Identifier

R-HSA-445079

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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L1 cross linking can activate MAPK cascade components MEK1/2, ERK1/2, as well as Src, Raf-1,and p90rsk. MAP kinase signaling requires endocytosis mediated by Src. ERK2 can phos-phorylate internalized L1 at serine residues 1204 and 1248. This phosphorylation may increase the neurite growth.

Literature References

PubMed ID	Title	Journal	Year
10818153	A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis Schmid, RS, Pruitt, WM, Maness, PF	J Neurosci	2000
10608864	Activation of the MAPK signal cascade by the neural cell adhesion molecule L1 requires L1 internalization Schaefer, AW, Kamiguchi, H, Wong, EV, Beach, CM, Landreth, G, Lemmon, V	J Biol Chem	1999