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Transport of L1 from C-domain to P-domain
Stable Identifier
R-HSA-445077
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Transport of L1 from C-domain to P-domain (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Endocytosis is followed by the vesicular transport and recycling of L1 from central (C)-domain into the peripheral (P)-domain of growth cones.
Microtubules serve as a rail on which motor proteins convey L1 containing organelles. KIF4 is a plus end motor protein involved in the anterograde transport of L1 containing vesicles along microtubules.
Participants
Input
KIF4 dimer [cytosol]
(Homo sapiens)
L1:AP-2 Clathrin complex [endosome]
(Homo sapiens)
Microtubule [cytosol]
(Homo sapiens)
Output
AP2 clathrin:L1:KIF4:microtubule [cytosol]
(Homo sapiens)
Participates
as an event of
Recycling pathway of L1 (Homo sapiens)
Inferred From
Transport of L1 from C-domain to P-domain (Mus musculus)
Authored
Garapati, P V (2008-07-30)
Reviewed
Maness, PF (2010-02-16)
Created
Garapati, P V (2009-10-27)
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