Activation of Rac1 by VAV2

Stable Identifier
R-HSA-445064
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The small GTPase p21Rac1 is one of the important targets of VAV2 GEF activity. On L1 stimulation tyrosine phosphorylated VAV2, catalyses GDP/GTP exchange on Rac1.

Literature References
PubMed ID Title Journal Year
15597056 Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling

Schmid, RS, Midkiff, BR, Kedar, VP, Maness, PF

Neuroreport 2004
10818153 A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis

Schmid, RS, Pruitt, WM, Maness, PF

J Neurosci 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-Y172-VAV2 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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