Activation of Rac1 by VAV2

Stable Identifier
R-HSA-445064
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Activation of Rac1 by VAV2
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The small GTPase p21Rac1 is one of the important targets of VAV2 GEF activity. On L1 stimulation tyrosine phosphorylated VAV2, catalyses GDP/GTP exchange on Rac1.
Literature References
PubMed ID Title Journal Year
10818153 A MAP kinase-signaling pathway mediates neurite outgrowth on L1 and requires Src-dependent endocytosis

Schmid, RS, Pruitt, WM, Maness, PF

J Neurosci 2000
15597056 Adhesion molecule L1 stimulates neuronal migration through Vav2-Pak1 signaling

Schmid, RS, Midkiff, BR, Maness, PF, Kedar, VP

Neuroreport 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-Y172-VAV2 [cytosol]

Physical Entity
p-Y172-VAV2 [cytosol] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of Rac1 by VAV2 (Bos taurus)
Activation of Rac1 by VAV2 (Caenorhabditis elegans)
Activation of Rac1 by VAV2 (Canis familiaris)
Activation of Rac1 by VAV2 (Drosophila melanogaster)
Activation of Rac1 by VAV2 (Gallus gallus)
Activation of Rac1 by VAV2 (Mus musculus)
Activation of Rac1 by VAV2 (Rattus norvegicus)
Activation of Rac1 by VAV2 (Sus scrofa)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-27)
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