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INSL3(21-55) [extracellular region]
Stable Identifier
R-HSA-444906
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Insulin-like peptide 3 B chain, INSL3, INSL3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
INSL3(21-55) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51460 INSL3
Gene Names
INSL3, RLF, RLNL
Chain
signal peptide:1-20, peptide:21-55, propeptide:58-104, peptide:106-131
Reference Genes
BioGPS Gene:3640 INSL3
COSMIC (genes):INSL3 INSL3
COSMIC (genes):RLF INSL3
CTD Gene:3640 INSL3
dbSNP Gene:3640 INSL3
ENSEMBL:ENSG00000248099 INSL3
HGNC:6086 INSL3
KEGG:hsa:3640 INSL3
Monarch:3640 INSL3
NCBI Gene:3640 INSL3
OMIM:146738 INSL3
UCSC:P51460 INSL3
Reference Transcript
RefSeq:NM_005543.3 INSL3
RefSeq:NM_001265587.1 INSL3
Other Identifiers
11744966_a_at
1553594_PM_a_at
1553594_a_at
16870269
214400_PM_at
214400_at
214572_PM_s_at
214572_s_at
36301_at
3640
3854622
3854623
3854624
3854625
3854626
701_s_at
8035345
A_23_P209006
A_23_P309281
A_33_P3334828
GE552890
GE88024
GO:0001556
GO:0001664
GO:0002020
GO:0005102
GO:0005158
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0007193
GO:0007267
GO:0007283
GO:0008284
GO:0008285
GO:0008584
GO:0010634
GO:0022414
GO:0023052
GO:0043066
GO:0043950
GO:0048018
GO:0048471
GO:0048856
GO:0090303
GO:0098772
HMNXSV003022883
Hs.37062.1.S1_3p_a_at
Hs2.37062.1.S1_3p_s_at
ILMN_2226271
PH_hs_0002936
TC19001279.hg
Participates
as a component of
Insulin-like peptide 3 [extracellular region] (Homo sapiens)
Other forms of this molecule
INSL3(106-131) [extracellular region]
Inferred To
INSL3 [extracellular region]
(Bos taurus)
INSL3 [extracellular region]
(Canis familiaris)
INSL3 [extracellular region]
(Sus scrofa)
Insl3 [extracellular region]
(Mus musculus)
Insl3 [extracellular region]
(Rattus norvegicus)
Ilp4 [extracellular region]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001252516.1
,
NP_005534.2
ENSEMBL
ENST00000317306
,
ENSP00000369017
,
ENST00000379695
,
ENSP00000321724
,
ENSG00000248099
OpenTargets
ENSG00000248099
GeneCards
INSL3
HPA
ENSG00000248099-INSL3
PRO
P51460
Pharos - Targets
P51460
PDB
2H8B
,
2K6U
,
2K6T
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48200 IREB2
2
Ub-K-IREB2 [cytosol]
(R-HSA-5691152)
IREB2 [cytosol]
(R-HSA-5690876)
0.527
2
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