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RLN2(25-53) [extracellular region]
Stable Identifier
R-HSA-444870
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Relaxin-2 B chain, RLN2, REL2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
Relaxin receptor 2 binds relaxin 2 and INSL3 (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
RXFP2:RXFP2 ligands [plasma membrane] (Homo sapiens)
RXFP2 ligands [extracellular region] (Homo sapiens)
Relaxin-2 [extracellular region] (Homo sapiens)
RLN2(25-53) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04090 RLN2
Gene Names
RLN2
Chain
signal peptide:1-24, peptide:25-53, propeptide:56-157, peptide:162-185
Reference Genes
BioGPS Gene:6019 RLN2
COSMIC (genes):RLN2 RLN2
CTD Gene:6019 RLN2
dbSNP Gene:6019 RLN2
ENSEMBL:ENSG00000107014 RLN2
HGNC:10027 RLN2
KEGG:hsa:6019 RLN2
Monarch:6019 RLN2
NCBI Gene:6019 RLN2
OMIM:179740 RLN2
UCSC:P04090 RLN2
Reference Transcript
RefSeq:NM_134441.2 RLN2
RefSeq:NM_005059.3 RLN2
Other Identifiers
11738317_a_at
17092177
214519_PM_s_at
214519_s_at
31732_at
3197497
3197499
3197500
3197501
3197503
3197504
3197505
3197506
3197517
3197519
6019
8159977
A_23_P216455
GE59634
GO:0005179
GO:0005576
GO:0007165
GO:0007565
GO:0010628
GO:0022414
GO:0045766
GO:0048018
GO:0050790
GO:0098772
HMNXSV003029140
HMNXSV003048403
Hs.127032.0.S1_3p_a_at
ILMN_1744887
ILMN_1748529
PH_hs_0027816
PH_hs_0031646
TC09000889.hg
TC09002388.hg
X00948_at
Participates
as a component of
Relaxin-2 [extracellular region] (Homo sapiens)
Other forms of this molecule
RLN2(162-185) [extracellular region]
Inferred To
Rln1 [extracellular region]
(Mus musculus)
Rln1 [extracellular region]
(Rattus norvegicus)
RLN2 [extracellular region]
(Canis familiaris)
RLN2(25-53) [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_005050.2
,
NP_604390.1
ENSEMBL
ENSP00000371040
,
ENST00000381627
OpenTargets
ENSG00000107014
HPA
ENSG00000107014-RLN2
PRO
P04090
Pharos - Targets
P04090
PDB
2MV1
,
6RLX
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