Relaxin 3 receptor 2 binds relaxin 3 and INSL5

Stable Identifier
Reaction [binding]
Homo sapiens
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Relaxin-3 receptor 2 (RXFP4 or GPR100) is activated by relaxin-3 and by INSL5. Because of overlapping expression patterns between ligand and receptor Relaxin-3 receptor 2 is considered to be a high affinity INSL5 receptor.

Literature References
PubMed ID Title Journal Year
14522967 Identification of relaxin-3/INSL7 as a ligand for GPCR142

Liu, C, Chen, J, Sutton, S, Roland, B, Kuei, C, Farmer, N, Sillard, R, Lovenberg, TW

J Biol Chem 2003
15525639 INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

Liu, C, Kuei, C, Sutton, S, Chen, J, Bonaventure, P, Wu, J, Nepomuceno, D, Kamme, F, Tran, DT, Zhu, J, Wilkinson, T, Bathgate, R, Eriste, E, Sillard, R, Lovenberg, TW

J Biol Chem 2005
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Orthologous Events
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