Reactome | Relaxin 3 receptor 2 binds relaxin 3 and INSL5

Relaxin 3 receptor 2 binds relaxin 3 and INSL5

Stable Identifier

R-HSA-444859

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Relaxin receptors (Homo sapiens)
        
        Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)

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Relaxin 3 receptor 2 binds relaxin 3 and INSL5

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Relaxin-3 receptor 2 (RXFP4 or GPR100) is activated by relaxin-3 and by INSL5. Because of overlapping expression patterns between ligand and receptor Relaxin-3 receptor 2 is considered to be a high affinity INSL5 receptor.

Literature References

PubMed ID	Title	Journal	Year
15525639	INSL5 is a high affinity specific agonist for GPCR142 (GPR100) Sutton, S, Kuei, C, Bathgate, R, Wilkinson, T, Bonaventure, P, Eriste, E, Sillard, R, Liu, C, Tran, DT, Lovenberg, TW, Zhu, J, Nepomuceno, D, Kamme, F, Wu, J, Chen, J	J Biol Chem	2005
14522967	Identification of relaxin-3/INSL7 as a ligand for GPCR142 Kuei, C, Roland, B, Sutton, S, Lovenberg, TW, Farmer, N, Sillard, R, Chen, J, Liu, C	J Biol Chem	2003