Relaxin 3 receptor 2 binds relaxin 3 and INSL5

Stable Identifier
R-HSA-444859
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Relaxin-3 receptor 2 (RXFP4 or GPR100) is activated by relaxin-3 and by INSL5. Because of overlapping expression patterns between ligand and receptor Relaxin-3 receptor 2 is considered to be a high affinity INSL5 receptor.

Literature References
PubMed ID Title Journal Year
14522967 Identification of relaxin-3/INSL7 as a ligand for GPCR142

Liu, C, Chen, J, Sutton, S, Roland, B, Kuei, C, Farmer, N, Sillard, R, Lovenberg, TW

J Biol Chem 2003
15525639 INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

Liu, C, Kuei, C, Sutton, S, Chen, J, Bonaventure, P, Wu, J, Nepomuceno, D, Kamme, F, Tran, DT, Zhu, J, Wilkinson, T, Bathgate, R, Eriste, E, Sillard, R, Lovenberg, TW

J Biol Chem 2005
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created