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RLN3(26-52) [extracellular region]
Stable Identifier
R-HSA-444849
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Relaxin-3 B chain, RLN3, REL3_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin 3 receptor 1 binds relaxin 3 (Homo sapiens)
RXFP3:Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 ligands [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)
RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
Relaxin-2, Relaxin-3 [extracellular region] (Homo sapiens)
Relaxin-3 [extracellular region] (Homo sapiens)
RLN3(26-52) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8WXF3 RLN3
Gene Names
RLN3, INSL7, RXN3, ZINS4, UNQ6188/PRO20213
Chain
signal peptide:1-25, peptide:26-52, propeptide:55-118, peptide:119-142
Reference Genes
BioGPS Gene:117579 RLN3
COSMIC (genes):RLN3 RLN3
CTD Gene:117579 RLN3
dbSNP Gene:117579 RLN3
ENSEMBL:ENSG00000171136 RLN3
ENSEMBL_homo_sapiens_GENE:ENSG00000171136.7 RLN3
ENSEMBL_homo_sapiens_GENE:ENSG00000288474.1 RLN3
HGNC:17135 RLN3
KEGG Gene (Homo sapiens):117579 RLN3
Monarch:117579 RLN3
NCBI Gene:117579 RLN3
OMIM:606855 RLN3
UCSC:Q8WXF3 RLN3
Reference Transcript
RefSeq:NM_001311197.1 RLN3
RefSeq:NM_080864.3 RLN3
Other Identifiers
11756034_a_at
117579
1553403_PM_at
1553403_at
16858936
217702_3p_at
217702_PM_at
217702_at
3822545
3822546
3822547
3822548
3822550
3822552
3822553
3822554
8026265
ADDON002781.hg
A_23_P39008
A_33_P3226825
GE565352
GO:0001664
GO:0005179
GO:0005515
GO:0005576
GO:0007165
GO:0023052
GO:0048018
GO:0098772
HMNXSV003034409
Hs.255387.0.A1_3p_at
Hs.255387.0.A1_3p_x_at
Hs2.352155.1.S1_3p_at
ILMN_1717278
PH_hs_0017036
TC19000249.hg
Participates
as a component of
Relaxin-3 [extracellular region] (Homo sapiens)
Other forms of this molecule
RLN3(119-142) [extracellular region]
Inferred To
RLN3(26-52) [extracellular region]
(Bos taurus)
rln3a [extracellular region]
(Danio rerio)
RLN3 [extracellular region]
(Canis familiaris)
RLN3 [extracellular region]
(Sus scrofa)
Rln3 [extracellular region]
(Mus musculus)
Rln3 [extracellular region]
(Rattus norvegicus)
rln3 [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001298126.1
,
NP_543140.1
OpenTargets
ENSG00000171136
GeneCards
Q8WXF3
HPA
ENSG00000171136-RLN3
Ensembl
ENST00000673090
,
ENSG00000171136
,
ENSG00000288474
,
ENST00000431365
,
ENSP00000500641
,
ENSP00000397415
PRO
Q8WXF3
Pharos - Targets
Q8WXF3
PDB
2FHW
,
2K1V
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