Relaxin receptor 1 binds relaxin 2 and 3

Stable Identifier
R-HSA-444838
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Relaxin receptor 1 binds relaxin 2 and 3
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Relaxin receptor 1 (RXFP1 or LGR7) was identified as a receptor for porcine relaxin and subsequently shown to bind human relaxin-2 and relaxin-3.

Literature References
PubMed ID Title Journal Year
12506116 H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

Sudo, S, Kumagai, J, Nishi, S, Layfield, S, Ferraro, T, Bathgate, RA, Hsueh, AJ

J Biol Chem 2003
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Orthologous Events
Relaxin receptor 1 binds relaxin 2 and 3 (Bos taurus)
Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)
Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)
Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)
Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)
Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)
Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)
Authored
Jupe, S  (2009-10-26)
Reviewed
D'Eustachio, P  (2009-12-12)
Created
Jupe, S  (2009-10-26)