Relaxin receptor 1 binds relaxin 2 and 3

Stable Identifier
R-HSA-444838
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Relaxin receptor 1 binds relaxin 2 and 3
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Relaxin receptor 1 (RXFP1 or LGR7) was identified as a receptor for porcine relaxin and subsequently shown to bind human relaxin-2 and relaxin-3.

Literature References
PubMed ID Title Journal Year
12506116 H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

Kumagai, J, Bathgate, RA, Ferraro, T, Hsueh, AJ, Sudo, S, Layfield, S, Nishi, S

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
Orthologous Events
Relaxin receptor 1 binds relaxin 2 and 3 (Canis familiaris)
Relaxin receptor 1 binds relaxin 2 and 3 (Danio rerio)
Relaxin receptor 1 binds relaxin 2 and 3 (Gallus gallus)
Relaxin receptor 1 binds relaxin 2 and 3 (Mus musculus)
Relaxin receptor 1 binds relaxin 2 and 3 (Rattus norvegicus)
Relaxin receptor 1 binds relaxin 2 and 3 (Sus scrofa)
Relaxin receptor 1 binds relaxin 2 and 3 (Xenopus tropicalis)
Authored
Jupe, S  (2009-10-26)
Reviewed
D'Eustachio, P  (2009-12-11)
Created
Jupe, S  (2009-10-26)
Cite Us!