Reactome | RXFP1 [plasma membrane]

RXFP1 [plasma membrane]

Stable Identifier

R-HSA-444834

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Relaxin receptor 1, RXFP1_HUMAN, LGR7

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Leishmania infection (Homo sapiens)
    - Leishmania parasite growth and survival (Homo sapiens)
      - Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
        
        ADORA2B mediated anti-inflammatory cytokines production (Homo sapiens)
        
        ADORA2B (in Ade-Rib:ADORA2B:Heterotrimeric G-protein Gs) exchanges GDP for GTP on Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)
        
        RXFP1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HBX9 RXFP1

Gene Names

RXFP1, LGR7

Chain

chain:1-757

Reference Genes

BioGPS Gene:59350 RXFP1

COSMIC (genes):RXFP1 RXFP1

CTD Gene:59350 RXFP1

dbSNP Gene:59350 RXFP1

ENSEMBL:ENSG00000171509 RXFP1

HGNC:19718 RXFP1

KEGG Gene (Homo sapiens):59350 RXFP1

Monarch:59350 RXFP1

NCBI Gene:59350 RXFP1

OMIM:606654 RXFP1

UCSC:Q9HBX9 RXFP1

Reference Transcript

Other Identifiers

0002370025

11748207_a_at

11750399_a_at

11750990_a_at

11761923_a_at

1552715_a_at

16971910

231804_at

238206_at

2749507

2749508

2749520

2749523

2749524

2749525

2749526

2749528

2749529

2749530

2749531

2749532

2749533

2749534

2749535

2749536

2749537

2749540

2749541

2749542

2749543

2749544

2749545

2749546

2749547

2749548

2749549

59350

59756_at

79637_at

8098060

89447_at

A_14_P122746

A_23_P124534

A_23_P433050

GE61468

GE717026

GE80549

GO:0000003

GO:0002376

GO:0002862

GO:0003674

GO:0004930

GO:0005515

GO:0005575

GO:0005886

GO:0005887

GO:0006950

GO:0007165

GO:0007186

GO:0007188

GO:0007189

GO:0007190

GO:0007567

GO:0008150

GO:0008528

GO:0009755

GO:0016020

GO:0016021

GO:0030154

GO:0030198

GO:0042562

GO:0043167

GO:0046872

GO:0048856

GO:0060427

GO:0060658

HMNXSV003021334

Hs.179243.0.A1_3p_at

Hs.209446.0.S2_3p_at

Hs2.209446.1.S1_3p_s_at

ILMN_1749150

PH_hs_0022861

Participates

as an input of

Relaxin receptor 1 binds relaxin 2 and 3 (Homo sapiens)

as a member of

GPCRs that activate Gs [plasma membrane] (Homo sapiens)

as a component of

RXFP1:Relaxin-2,Relaxin-3 [plasma membrane] (Homo sapiens)

Inferred To

Homologues of RXFP1 [plasma membrane] (Drosophila melanogaster)

Lgr3 [plasma membrane] (Drosophila melanogaster)

lron-14 [plasma membrane] (Caenorhabditis elegans)

RXFP1 [plasma membrane] (Canis familiaris)

RXFP1 [plasma membrane] (Gallus gallus)

RXFP1 [plasma membrane] (Sus scrofa)

RXFP1 [plasma membrane] (Xenopus tropicalis)

Rxfp1 [plasma membrane] (Mus musculus)

Rxfp1 [plasma membrane] (Rattus norvegicus)

rxfp1 [plasma membrane] (Danio rerio)

Lgr4 [plasma membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_001240657.1, NP_001240658.1, NP_067647.2

Guide to Pharmacology - Targets

351

OpenTargets

ENSG00000171509

HPA

ENSG00000171509-RXFP1

GeneCards

Q9HBX9

ZINC target

Q9HBX9

Ensembl

ENSP00000434475, ENSP00000345889, ENST00000307765, ENSP00000303248, ENST00000470033, ENSP00000420712, ENST00000343542, ENSG00000171509, ENST00000471616

PRO

Q9HBX9

Pharos - Targets

Q9HBX9

GlyGen

Q9HBX9

PDB

2JM4, 2M7P

HMDB Protein

HMDBP02401

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q08499-2 PDE4D			0.462	3