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RXFP4 [plasma membrane]
Stable Identifier
R-HSA-444826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Relaxin-3 receptor 2, RL3R2_HUMAN, GPR100
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Relaxin receptors (Homo sapiens)
Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
RXFP4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDU9 RXFP4
Gene Names
RXFP4, GPCR142, GPR100, RLN3R2
Chain
chain:1-374
Reference Genes
BioGPS Gene:339403 RXFP4
COSMIC (genes):RXFP4 RXFP4
CTD Gene:339403 RXFP4
dbSNP Gene:339403 RXFP4
ENSEMBL:ENSG00000173080 RXFP4
HGNC:14666 RXFP4
KEGG:hsa:339403 RXFP4
Monarch:339403 RXFP4
NCBI Gene:339403 RXFP4
OMIM:609043 RXFP4
UCSC:Q8TDU9 RXFP4
Reference Transcript
RefSeq:NM_181885.2 RXFP4
Other Identifiers
11738020_at
16671884
2361197
2361198
2361199
2361200
339403
7906069
ADDON002862.hg
A_14_P111354
A_24_P154142
GO:0004930
GO:0005515
GO:0005886
GO:0007186
GO:0007218
GO:0008528
GO:0016020
GO:0060089
GO:2000253
HMNXSV003034055
ILMN_1806099
PH_hs_0033746
TC01001308.hg
Participates
as an input of
Relaxin 3 receptor 2 binds relaxin 3 and INSL5 (Homo sapiens)
as a component of
RXFP4:RXFP4 ligands [plasma membrane] (Homo sapiens)
Inferred To
rxfp3.2b [plasma membrane]
(Danio rerio)
Rxfp4 [plasma membrane]
(Mus musculus)
RXFP4 [plasma membrane]
(Caenorhabditis elegans)
RXFP4 [plasma membrane]
(Gallus gallus)
RXFP4 [plasma membrane]
(Sus scrofa)
Homologues of RXFP4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of RXFP4 [plasma membrane]
(Danio rerio)
npr-27 [plasma membrane]
(Caenorhabditis elegans)
rxfp3 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_871001.1
Guide to Pharmacology - Targets
354
ENSEMBL
ENSP00000357301
,
ENST00000368318
OpenTargets
ENSG00000173080
HPA
ENSG00000173080-RXFP4
ZINC - Substances
RL3R2_HUMAN
ZINC target
Q8TDU9
PRO
Q8TDU9
Pharos - Targets
Q8TDU9
GlyGen
Q8TDU9
HMDB Protein
HMDBP08168
PDB
7YK7
,
7YK6
,
7YJ4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48165 GJA8
1
GJA8 [endoplasmic reticulum membrane]
(R-HSA-190702)
0.556
3
UniProt:Q9NWS8 RMND1
0.527
2
UniProt:O75845 SC5D
1
SC5D [endoplasmic reticulum membrane]
(R-HSA-195662)
0.527
2
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