Reactome | C3AR1 [plasma membrane]

C3AR1 [plasma membrane]

Stable Identifier

R-HSA-444727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C3a anaphylatoxin chemotactic receptor, C3AR_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q8TBA6 GOLGA5

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Cell recruitment (pro-inflammatory response) (Homo sapiens)
        
        Purinergic signaling in leishmaniasis infection (Homo sapiens)
        
        C3a receptor binds anaphylatoxin C3a (Homo sapiens)
        
        C3AR1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16581 C3AR1

Gene Names

C3AR1, AZ3B, C3R1, HNFAG09

Chain

chain:1-482

Reference Genes

BioGPS Gene:719 C3AR1

COSMIC (genes):C3AR1 C3AR1

CTD Gene:719 C3AR1

dbSNP Gene:719 C3AR1

ENSEMBL:ENSG00000171860 C3AR1

ENSEMBL_homo_sapiens_GENE:ENSG00000171860.5 C3AR1

HGNC:1319 C3AR1

KEGG Gene (Homo sapiens):719 C3AR1

Monarch:719 C3AR1

NCBI Gene:719 C3AR1

OMIM:605246 C3AR1

UCSC:Q16581 C3AR1

Reference Transcript

Other Identifiers

11721099_at

16760889

209906_PM_at

209906_at

32068_at

3442938

3442940

3442942

3442943

3442944

3442945

3442946

3442947

3442948

3442949

3442950

3442951

3442952

3442954

719

7960874

A_23_P2431

GE565218

GE59287

GO:0002376

GO:0002430

GO:0002682

GO:0003013

GO:0004875

GO:0004876

GO:0004878

GO:0004930

GO:0005764

GO:0005773

GO:0005886

GO:0006935

GO:0006954

GO:0007165

GO:0007186

GO:0007200

GO:0007204

GO:0008015

GO:0010575

GO:0010759

GO:0016020

GO:0019722

GO:0023052

GO:0031410

GO:0035577

GO:0035579

GO:0038178

GO:0043226

GO:0045766

GO:0048583

GO:0048856

GO:0048870

GO:0060089

GO:0090023

HMNXSV003040667

ILMN_1787529

PH_hs_0009397

TC12001171.hg

U28488_s_at

g1511643_3p_at

Participates

as a member of

as an input of

C3a receptor binds anaphylatoxin C3a (Homo sapiens)

as a component of

C3AR1:C3a [plasma membrane] (Homo sapiens)

Other forms of this molecule

C3AR1 [azurophil granule membrane]

C3AR1 [specific granule membrane]

Inferred To

c3ar1 [plasma membrane] (Xenopus tropicalis)

C3ar1 [plasma membrane] (Mus musculus)

C3ar1 [plasma membrane] (Rattus norvegicus)

C3AR1 [plasma membrane] (Bos taurus)

C3AR1 [plasma membrane] (Canis familiaris)

C3AR1 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_001313406.1, NP_004045.1, NP_001313404.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000171860

GeneCards

Q16581

ZINC - Substances

C3AR_HUMAN

HPA

ENSG00000171860-C3AR1

ZINC target

Q16581

Ensembl

ENST00000307637, ENSP00000302079, ENSG00000171860

PRO

Q16581

Pharos - Targets

Q16581

ZINC - Predictions - Purchasable

C3AR_HUMAN

PDB

8JA3, 8IA8, 8I95, 8I97, 8I9L, 8HK2, 8I9A, 8HK3, 8I9S, 8J6D

Interactors (52)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NY26 SLC39A1	1	SLC39A1 [plasma membrane] (R-HSA-442329)	0.527	2
UniProt:Q6P1Q0 LTMD1			0.527	2
UniProt:Q8N2A8 PLD6	2	PLD6 [endoplasmic reticulum membrane] (R-HSA-1498811) PLD6 [mitochondrial outer membrane] (R-HSA-5601898)	0.527	2
UniProt:Q9NX00 TM160			0.527	2
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.527	2
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.527	2
UniProt:P30519 HMOX2	3	HMOX2 [plasma membrane] (R-HSA-6799676) HMOX2 [specific granule membrane] (R-HSA-6799628) HMOX2 [endoplasmic reticulum membrane] (R-HSA-189391)	0.527	2
UniProt:Q9GZM5 YIPF3			0.527	2
UniProt:Q6P1A2 LPCAT3	1	LPCAT3 [endoplasmic reticulum membrane] (R-HSA-428994)	0.527	2
UniProt:P61019 RAB2A	3	GGC-RAB2A [cytosol] (R-HSA-8873963) RAB2A [cytosol] (R-HSA-8873716) RAB2A [Golgi membrane] (R-HSA-2422386)	0.527	2
UniProt:Q92968 PEX13	2	PEX13 [cytosol] (R-HSA-9603795) PEX13 [peroxisomal membrane] (R-HSA-452790)	0.527	2
UniProt:Q9UBV7 B4GALT7	4	B4GALT7 A186D [Golgi membrane] (R-HSA-3621785) B4GALT7 L206P [Golgi membrane] (R-HSA-3621790) B4GALT7 R270C [Golgi membrane] (R-HSA-3621734) B4GALT7 [Golgi membrane] (R-HSA-1889950)	0.527	2
UniProt:Q9HBH5 RDH14	1	RDH14 [endoplasmic reticulum membrane] (R-HSA-2980933)	0.527	2
UniProt:Q8N8J7 F241A			0.527	2
UniProt:Q8WUY8 NAT14			0.527	2
UniProt:O94886 TMEM63A	3	TMEM63A [specific granule membrane] (R-HSA-6799721) TMEM63A [plasma membrane] (R-HSA-6800445) TMEM63A [tertiary granule membrane] (R-HSA-6800945)	0.527	2
UniProt:O75907 DGAT1	3	DGAT1 [plasma membrane] (R-HSA-6806313) DGAT1 [specific granule membrane] (R-HSA-6799564) DGAT1 [endoplasmic reticulum membrane] (R-HSA-53579)	0.527	2
UniProt:A6NFQ2 TCAF2			0.527	2
UniProt:O95858 TSPAN15	2	TSPAN15 [plasma membrane] (R-HSA-9010043) TSPAN15 [endoplasmic reticulum lumen] (R-HSA-9010117)	0.527	2
UniProt:Q9NRZ5 AGPAT4	1	AGPAT4 [endoplasmic reticulum membrane] (R-HSA-61809)	0.527	2
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.527	2
UniProt:Q7Z7E8 UBE2Q1	1	UBE2Q1 [cytosol] (R-HSA-947629)	0.527	2
UniProt:Q8IVQ6 ZDHHC21	1	ZDHHC21 [Golgi membrane] (R-HSA-203757)	0.527	2
UniProt:Q15800 MSMO1	1	MSMO1 [endoplasmic reticulum membrane] (R-HSA-194648)	0.527	2
UniProt:Q9Y375 NDUFAF1	1	NDUFAF1 [mitochondrial inner membrane] (R-HSA-5689050)	0.527	2
UniProt:O75110 ATP9A	1	ATP9A [plasma membrane] (R-HSA-939754)	0.527	2
UniProt:A0PK00 T120B			0.527	2
UniProt:Q8TBA6 GOLGA5	2	GOLGA5 [transport vesicle] (R-HSA-8847517) GOLGA5 [Golgi membrane] (R-HSA-8847514)	0.527	2
UniProt:Q00765 REEP5			0.527	2
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:Q8NHS3 MFSD8			0.527	2
UniProt:O43674 NDUFB5	1	NDUFB5 [mitochondrial inner membrane] (R-HSA-163944)	0.527	2
UniProt:Q9NXB9 ELOVL2	1	ELOVL2 [endoplasmic reticulum membrane] (R-HSA-548677)	0.527	2
UniProt:Q9H5K3 POMK	1	POMK [endoplasmic reticulum membrane] (R-HSA-8879120)	0.527	2
UniProt:Q6Y1H2 HACD2	1	PTPLB [endoplasmic reticulum membrane] (R-HSA-5676075)	0.527	2
UniProt:Q96MH6 DIESL			0.527	2
UniProt:Q8NBX0 SCCPDH	2	SCCPDH [extracellular region] (R-HSA-8862997) SCCPDH [platelet alpha granule lumen] (R-HSA-8862982)	0.527	2
UniProt:Q92633 LPAR1	1	LPAR1 [plasma membrane] (R-HSA-419354)	0.527	2
UniProt:Q8IUH4 ZDH13			0.527	2
UniProt:O75845 SC5D	1	SC5D [endoplasmic reticulum membrane] (R-HSA-195662)	0.527	2
UniProt:P17706 PTPN2	3	p-PTPN2 [cytosol] (R-HSA-9836510) PTPN2 [nucleoplasm] (R-HSA-9008891) PTPN2 [cytosol] (R-HSA-997292)	0.527	2
UniProt:O43808 SLC25A17	2	SLC25A17 [cytosol] (R-HSA-9603781) SLC25A17 [peroxisomal membrane] (R-HSA-389642)	0.527	2
UniProt:O95159 ZFPL1			0.527	2
UniProt:Q8N5B7 CERS5	1	CERS5 [endoplasmic reticulum membrane] (R-HSA-428168)	0.527	2
UniProt:Q96MV1 TLCD4			0.527	2
UniProt:Q8N6M3 FITM2	1	FITM2 [endoplasmic reticulum membrane] (R-HSA-8857678)	0.527	2
UniProt:Q96NT0 CCDC115	1	CCDC115 [endoplasmic reticulum membrane] (R-HSA-9714329)	0.527	2
UniProt:Q3ZAQ7 VMA21			0.527	2
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.527	2
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.527	2
UniProt:O43913 ORC5	1	ORC5 [nucleoplasm] (R-HSA-68516)	0.527	2
UniProt:Q6ZMG9 CERS6	1	CERS6 [endoplasmic reticulum membrane] (R-HSA-428145)	0.527	2

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