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TAS1R3 [plasma membrane]
Stable Identifier
R-HSA-444724
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 1 member 3, Sweet taste receptor T1R3, TS1R3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS1R2:TAS1R3:sweet compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Sweet compound binds sweet taste receptor (TAS1R2:TAS1R3) (Homo sapiens)
TAS1R2:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:sweet compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R2:TAS1R3:sweet compound, GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
TAS1R2:TAS1R3:Sweet compound:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
T1R2/T1R3 dimer is a sweet taste receptor (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3:Sweet taste compounds [plasma membrane] (Homo sapiens)
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7RTX0 TAS1R3
Gene Names
TAS1R3, T1R3, TR3
Chain
signal peptide:1-20, chain:21-852
Reference Genes
BioGPS Gene:83756 TAS1R3
COSMIC (genes):TAS1R3 TAS1R3
CTD Gene:83756 TAS1R3
dbSNP Gene:83756 TAS1R3
ENSEMBL:ENSG00000169962 TAS1R3
HGNC:15661 TAS1R3
KEGG:hsa:83756 TAS1R3
Monarch:83756 TAS1R3
NCBI Gene:83756 TAS1R3
OMIM:605865 TAS1R3
UCSC:Q7RTX0 TAS1R3
Reference Transcript
RefSeq:NM_152228.2 TAS1R3
Other Identifiers
11740945_at
16657737
2315787
2315788
2315789
2315790
2315791
2315792
2315793
2315795
2315796
2315798
2315799
2315800
2315801
2315802
2315803
2315804
2315805
2315807
4041802
4041803
4041804
4041806
4041807
4041808
4041809
4041810
4041811
4041812
4041814
4041815
4041817
4041818
4041819
4041820
4041822
7896921
83756
A_33_P3260989
A_33_P3359084
GO:0001582
GO:0004930
GO:0005794
GO:0005886
GO:0007186
GO:0008527
GO:0016020
GO:0033041
GO:0043226
GO:0050877
GO:0050909
GO:0050916
GO:0050917
GO:0060089
GO:1903767
HMNXSV003016524
HMNXSV003035573
ILMN_1798875
ILMN_2108135
PH_hs_0028154
TC01000035.hg
Participates
as a component of
TAS1R2:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
Inferred To
TAS1R3 [plasma membrane]
(Bos taurus)
TAS1R3 [plasma membrane]
(Canis familiaris)
TAS1R3 [plasma membrane]
(Sus scrofa)
tas1r3 [plasma membrane]
(Danio rerio)
Tas1r3 [plasma membrane]
(Mus musculus)
Tas1r3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_689414.1
Guide to Pharmacology - Targets
658
ENSEMBL
ENSP00000344411
,
ENST00000339381
OpenTargets
ENSG00000169962
HPA
ENSG00000169962-TAS1R3
PRO
Q7RTX0
Pharos - Targets
Q7RTX0
GlyGen
Q7RTX0
HMDB Protein
HMDBP10823
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