Reactome | GPR4 [plasma membrane]

GPR4 [plasma membrane]

Stable Identifier

R-HSA-444708

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G-protein coupled receptor 4, GPR4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46093 GPR4

Gene Names

GPR4

Chain

chain:1-362

Reference Genes

BioGPS Gene:2828 GPR4

COSMIC (genes):GPR4 GPR4

CTD Gene:2828 GPR4

dbSNP Gene:2828 GPR4

ENSEMBL:ENSG00000177464.5 GPR4

HGNC:4497 GPR4

KEGG Gene (Homo sapiens):2828 GPR4

Monarch:2828 GPR4

NCBI Gene:2828 GPR4

OMIM:600551 GPR4

UCSC:P46093 GPR4

Reference Transcript

Other Identifiers

11730392_at

11730393_at

16873352

206236_PM_at

206236_at

211266_PM_s_at

211266_s_at

2828

35460_at

3865504

3865505

3865506

3865507

3865508

8037614

A_23_P16047

A_23_P357284

GE59006

GO:0003013

GO:0004930

GO:0005886

GO:0006954

GO:0007155

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0010447

GO:0016020

GO:0016021

GO:0016525

GO:0023052

GO:0030154

GO:0030155

GO:0035025

GO:0042060

GO:0043114

GO:0048856

GO:0050729

GO:0051482

GO:0060055

GO:0060089

GO:0072144

HMNXSV003043667

ILMN_2074477

PH_hs_0028784

TC19002713.hg

U21051_rna1_at

g1015420_3p_a_at

g4885334_3p_at

Participates

as a member of

pH sensing receptors [plasma membrane] (Homo sapiens)

Inferred To

GPR4 [plasma membrane] (Bos taurus)

GPR4 [plasma membrane] (Danio rerio)

gpr4 [plasma membrane] (Xenopus tropicalis)

Gpr4 [plasma membrane] (Mus musculus)

Gpr4 [plasma membrane] (Rattus norvegicus)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_005273.1, XP_016882096.1, XP_016882097.1

Guide to Pharmacology - Targets

OpenTargets

ENSG00000177464

GeneCards

P46093

HPA

ENSG00000177464-GPR4

Ensembl

ENSP00000319744, ENST00000323040, ENSG00000177464

PRO

P46093

Pharos - Targets

P46093