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T1R1/T1R3 dimer is the umami taste receptor
Stable Identifier
R-HSA-444705
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)
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Dimers of the T1R1 and T1R3 receptors responds to the umami taste stimulus L-glutamate, signaling via the Gi family G-protein Gustducin (Caicedo et al. 2003).
Literature References
PubMed ID
Title
Journal
Year
11917125
Human receptors for sweet and umami taste
Xu, H
,
Zoller, M
,
Staszewski, L
,
Li, X
,
Adler, E
,
Durick, K
Proc Natl Acad Sci U S A
2002
Participants
Input
L-Glu [extracellular region]
TAS1R1:TAS1R3 [plasma membrane]
(Homo sapiens)
Output
TAS1R1:TAS1R3:L-Glu [plasma membrane]
(Homo sapiens)
Participates
as an event of
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
Orthologous Events
T1R1/T1R3 dimer is the umami taste receptor (Bos taurus)
T1R1/T1R3 dimer is the umami taste receptor (Canis familiaris)
T1R1/T1R3 dimer is the umami taste receptor (Danio rerio)
T1R1/T1R3 dimer is the umami taste receptor (Mus musculus)
T1R1/T1R3 dimer is the umami taste receptor (Rattus norvegicus)
T1R1/T1R3 dimer is the umami taste receptor (Sus scrofa)
Authored
Jupe, S (2009-10-23)
Reviewed
D'Eustachio, P (2009-12-12)
Created
Jupe, S (2009-10-26)
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