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NPSR1 [plasma membrane]
Stable Identifier
R-HSA-444704
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Neuropeptide S receptor, NPSR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Neuropeptide S receptor binds neuropeptide S (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
NPSR1:NPS [plasma membrane] (Homo sapiens)
NPSR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6W5P4 NPSR1
Gene Names
NPSR1, GPR154, GPRA, PGR14
Chain
chain:1-371
Reference Genes
BioGPS Gene:387129 NPSR1
COSMIC (genes):NPSR1 NPSR1
CTD Gene:387129 NPSR1
dbSNP Gene:387129 NPSR1
ENSEMBL:ENSG00000187258 NPSR1
HGNC:23631 NPSR1
KEGG:hsa:387129 NPSR1
Monarch:387129 NPSR1
NCBI Gene:387129 NPSR1
OMIM:608595 NPSR1
UCSC:Q6W5P4 NPSR1
Reference Transcript
RefSeq:NM_207173.1 NPSR1
RefSeq:NM_207172.1 NPSR1
RefSeq:NM_001300934.1 NPSR1
RefSeq:NM_001300935.1 NPSR1
RefSeq:NM_001300933.1 NPSR1
Other Identifiers
11752975_a_at
11752985_a_at
11753482_a_at
17045106
2996754
2996755
2996769
2996770
2996798
2996800
2996806
2996807
2996809
2996812
2996816
2996817
2996818
2996819
2996820
2996821
2996822
2996823
2996824
2996831
2996832
387129
8132270
A_23_P19886
A_33_P3417113
GO:0004930
GO:0005000
GO:0005737
GO:0005886
GO:0007186
GO:0007218
GO:0008188
GO:0016020
GO:0042755
GO:0051281
GO:0060013
GO:0060089
GO:0070374
GO:1903999
GO:2000293
HMNXSV003012669
HMNXSV003016089
HMNXSV003026829
ILMN_1654534
ILMN_1704206
ILMN_1720468
TC07000222.hg
TC07002248.hg
Participates
as a member of
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as an input of
Neuropeptide S receptor binds neuropeptide S (Homo sapiens)
as a component of
NPSR1:NPS [plasma membrane] (Homo sapiens)
Inferred To
npsr1 [plasma membrane]
(Xenopus tropicalis)
NPSR1 [plasma membrane]
(Bos taurus)
NPSR1 [plasma membrane]
(Canis familiaris)
NPSR1 [plasma membrane]
(Gallus gallus)
NPSR1 [plasma membrane]
(Sus scrofa)
Npsr1 [plasma membrane]
(Mus musculus)
Npsr1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_997056.1
,
NP_001287863.1
,
NP_001287862.1
,
NP_001287864.1
,
NP_997055.1
Guide to Pharmacology - Targets
302
OpenTargets
ENSG00000187258
ENSEMBL
ENST00000359791
,
ENSP00000434955
,
ENSP00000379402
,
ENST00000381553
,
ENST00000381544
,
ENST00000360581
,
ENST00000381542
,
ENSP00000433258
,
ENST00000465305
,
ENSP00000353788
,
ENSP00000370950
,
ENST00000381539
,
ENSP00000370953
,
ENST00000531252
,
ENSP00000352839
,
ENSP00000370955
,
ENSP00000370965
,
ENST00000396095
HPA
ENSG00000187258-NPSR1
ZINC - Substances
NPSR1_HUMAN
ZINC target
Q6W5P4
PRO
Q6W5P4
Pharos - Targets
Q6W5P4
GlyGen
Q6W5P4
ZINC - Predictions - Purchasable
NPSR1_HUMAN
HMDB Protein
HMDBP02381
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