Reactome | GPR132 [plasma membrane]

GPR132 [plasma membrane]

Stable Identifier

R-HSA-444699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G2A, Probable G-protein coupled receptor 132, GP132_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNW8 GPR132

Gene Names

GPR132, G2A

Chain

chain:1-380

Reference Genes

BioGPS Gene:29933 GPR132

COSMIC (genes):GPR132 GPR132

CTD Gene:29933 GPR132

dbSNP Gene:29933 GPR132

ENSEMBL:ENSG00000183484 GPR132

HGNC:17482 GPR132

KEGG:hsa:29933 GPR132

Monarch:29933 GPR132

NCBI Gene:29933 GPR132

OMIM:606167 GPR132

UCSC:Q9UNW8 GPR132

Reference Transcript

Other Identifiers

11735793_a_at

11747649_a_at

11755482_x_at

16797224

221140_PM_s_at

221140_s_at

223887_3p_at

223887_PM_at

223887_at

29933

3581403

3581405

3581406

3581407

3581408

3581409

3581410

3581411

3581412

3581413

3581414

3581416

3581421

7981530

A_23_P128808

A_24_P201994

GE61761

GO:0000082

GO:0004930

GO:0005886

GO:0007186

GO:0010972

GO:0016020

GO:0060089

HMNXSV003026906

ILMN_1811171

PH_hs_0021043

TC14001564.hg

g13528716_3p_at

g13528716_3p_x_at

g7019386_3p_a_at

Participates

as a member of

pH sensing receptors [plasma membrane] (Homo sapiens)

Inferred To

GPR132 [plasma membrane] (Bos taurus)

GPR132 [plasma membrane] (Canis familiaris)

GPR132 [plasma membrane] (Gallus gallus)

GPR132 [plasma membrane] (Sus scrofa)

gpr132 [plasma membrane] (Xenopus tropicalis)

Gpr132 [plasma membrane] (Mus musculus)

Gpr132 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001265623.1, NP_001265625.1, NP_001265624.1, NP_037477.1

Guide to Pharmacology - Targets

128

ENSEMBL

ENST00000392585, ENST00000539291, ENSP00000328818, ENSG00000183484, ENSP00000438094, ENST00000329797, ENSP00000376364

OpenTargets

ENSG00000183484

GeneCards

GPR132

HPA

ENSG00000183484-GPR132

PRO

Q9UNW8

Pharos - Targets

Q9UNW8

GlyGen

Q9UNW8

PDB

8HVI, 8HQE, 8HQN, 8HQM