Reactome | GPR132 [plasma membrane]

GPR132 [plasma membrane]

Stable Identifier

R-HSA-444699

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G2A, Probable G-protein coupled receptor 132, GP132_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR132 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9UNW8 GPR132

Gene Names

GPR132, G2A

Chain

chain:1-380

Reference Genes

BioGPS Gene:29933 GPR132

COSMIC (genes):GPR132 GPR132

CTD Gene:29933 GPR132

dbSNP Gene:29933 GPR132

ENSEMBL:ENSG00000183484 GPR132

HGNC:17482 GPR132

KEGG Gene (Homo sapiens):29933 GPR132

Monarch:29933 GPR132

NCBI Gene:29933 GPR132

OMIM:606167 GPR132

UCSC:Q9UNW8 GPR132

Reference Transcript

Other Identifiers

0000630435

11735793_a_at

11747649_a_at

11755482_x_at

16797224

221140_s_at

223887_3p_at

223887_at

29694

29695

29933

3581403

3581405

3581406

3581407

3581408

3581409

3581410

3581411

3581413

3581414

3581416

3581421

7981530

A_23_P128808

A_24_P201994

AAD47380

AAH84546

AAP35921

AB465599

AB465600

ABY87920

AF083955

AK292142

AK303654

AL512356

BAF84831

BAG64656

BAG84609

BAG84610

BC004555

BC084546

BT007257

CCDS61567

CCDS9997

CH471061

EAW81898

ENSG00000183484

ENSP00000328818

ENSP00000376364

ENSP00000438094

ENST00000329797

ENST00000329797.7

ENST00000392585

ENST00000392585.2

ENST00000539291

ENST00000539291.6

EntrezGene:29933

EntrezGene:GPR132

EU432121

F8VRH8

g13528716_3p_at

g13528716_3p_x_at

g7019386_3p_a_at

GE61761

GO:0000082

GO:0000278

GO:0003674

GO:0004930

GO:0005575

GO:0005623

GO:0005886

GO:0007049

GO:0007165

GO:0007186

GO:0008150

GO:0010972

GO:0016020

GO:0016021

GPR132

GPR132-201

GPR132-202

GPR132-203

HGNC:17482

HPA029694

HPA029695

ILMN_1811171

IPR000276

IPR005388

IPR017452

MIM:606167

NM_001278694

NM_001278695

NM_013345

NP_001265623

NP_001265624

NP_037477

PF00001

PH_hs_0021043

PR00237

PR01563

TC14001564.hg

UPI0000050461

UPI00001B2494

Participant Of

hasMember

pH sensing receptors [plasma membrane]

Inferred To

GPR132 [plasma membrane] (Bos taurus)

GPR132 [plasma membrane] (Canis familiaris)

GPR132 [plasma membrane] (Danio rerio)

GPR132 [plasma membrane] (Gallus gallus)

GPR132 [plasma membrane] (Mus musculus)

GPR132 [plasma membrane] (Rattus norvegicus)

GPR132 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001265625.1, NP_001265623.1, NP_037477.1, NP_001265624.1

OpenTargets

ENSG00000183484

GeneCards

Q9UNW8

PRO

Q9UNW8