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HCAR2 [plasma membrane]
Stable Identifier
R-HSA-444667
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Niacin receptor 1, NIACR1, NIAR1_HUMAN, HM74A, GPR109A
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
HCAR2 binds HCAR2 ligands (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
Hydroxycarboxylic acid-binding receptors (Homo sapiens)
HCAR2 binds HCAR2 ligands (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
HCAR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8TDS4 HCAR2
Gene Names
HCAR2, GPR109A, HCA2, HM74A, NIACR1
Chain
chain:1-363
Reference Genes
BioGPS Gene:338442 HCAR2
COSMIC (genes):HCAR2 HCAR2
CTD Gene:338442 HCAR2
dbSNP Gene:338442 HCAR2
ENSEMBL:ENSG00000182782 HCAR2
HGNC:24827 HCAR2
KEGG:hsa:338442 HCAR2
Monarch:338442 HCAR2
NCBI Gene:338442 HCAR2
OMIM:609163 HCAR2
UCSC:Q8TDS4 HCAR2
Reference Transcript
RefSeq:NM_177551.3 HCAR2
Other Identifiers
11722615_s_at
11724835_s_at
16771797
205220_PM_at
205220_at
338442
3475784
3475785
3475786
3475787
3475788
3475789
3475790
3475791
3475797
3475798
3475799
3475801
3475805
34951_at
7967318
A_23_P329924
D10923_at
GE57047
GO:0001781
GO:0004930
GO:0005886
GO:0006915
GO:0007186
GO:0012501
GO:0016020
GO:0030054
GO:0033031
GO:0050995
GO:0060089
GO:0070165
GO:0070553
HMNXSV003009215
ILMN_1750497
ILMN_1791138
PH_hs_0040321
TC12002078.hg
g5174460_3p_at
Participates
as an input of
HCAR2 binds HCAR2 ligands (Homo sapiens)
as a component of
HCAR2:HCAR2 ligands [plasma membrane] (Homo sapiens)
Inferred To
hcar1-4 [plasma membrane]
(Danio rerio)
HCAR2 [plasma membrane]
(Bos taurus)
HCAR2 [plasma membrane]
(Canis familiaris)
HCAR2 [plasma membrane]
(Sus scrofa)
Hcar2 [plasma membrane]
(Mus musculus)
Hcar2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_808219.1
ZINC - World Drugs
HCAR2_HUMAN
Guide to Pharmacology - Targets
312
OpenTargets
ENSG00000182782
ENSEMBL
ENSP00000375066
,
ENST00000328880
ZINC - FDA approved
HCAR2_HUMAN
ZINC - Substances
HCAR2_HUMAN
ZINC - Biogenic
HCAR2_HUMAN
ZINC target
Q8TDS4
PRO
Q8TDS4
GlyGen
Q8TDS4
PDB
8IYH
,
8I7W
,
8IJB
,
8IJD
,
8IHI
,
7ZLY
,
8I7V
,
8IHB
,
8IJA
,
8JER
,
7XK2
,
8K5C
,
8K5D
,
8K5B
,
8IHF
,
8JHN
,
8IY9
,
8IHH
,
8J6I
,
8J6R
,
8H2G
,
8JII
,
8J6J
,
7ZL9
,
8JHY
,
8J6L
,
8JIM
,
8JIL
,
8IJ3
,
8J6Q
,
8JZ7
,
8IYW
,
8J6P
ZINC - Investigational
HCAR2_HUMAN
ZINC - Metabolites
HCAR2_HUMAN
HPA
ENSG00000182782-HCAR2
Pharos - Targets
Q8TDS4
ZINC - Predictions - Purchasable
HCAR2_HUMAN
HMDB Protein
HMDBP02825
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