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TAS1R1 [plasma membrane]
Stable Identifier
R-HSA-444666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 1 member 1, T1R1, TS1R1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
GNAT3 exchanges GDP for GTP in L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP and GNAT3:GTP, and GNB1,3:GNG13 (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
L-Glutamate or L-Aspartate and 5' nucleotide bind umami taste receptor (TAS1R1:TAS1R3) (Homo sapiens)
L-Glu,L-Asp:GMP,IMP:TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu,L-Asp:GMP,IMP [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T1R1/T1R3 dimer is the umami taste receptor (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3:L-Glu [plasma membrane] (Homo sapiens)
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
TAS1R1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q7RTX1 TAS1R1
Gene Names
TAS1R1, GPR70, T1R1, TR1, GM148
Chain
signal peptide:1-20, chain:21-841
Reference Genes
BioGPS Gene:80835 TAS1R1
COSMIC (genes):TAS1R1 TAS1R1
CTD Gene:80835 TAS1R1
dbSNP Gene:80835 TAS1R1
ENSEMBL:ENSG00000173662.21 TAS1R1
HGNC:14448 TAS1R1
KEGG Gene (Homo sapiens):80835 TAS1R1
Monarch:80835 TAS1R1
NCBI Gene:80835 TAS1R1
OMIM:606225 TAS1R1
UCSC:Q7RTX1 TAS1R1
Reference Transcript
RefSeq:NM_177540.2 TAS1R1
RefSeq:NM_138697.3 TAS1R1
Other Identifiers
11732864_a_at
11741685_a_at
1555417_PM_a_at
1555417_a_at
1564883_PM_a_at
1564883_a_at
16658414
2318344
2318345
2318346
2318350
2318351
2318352
2318353
2318354
2318355
2318356
2318357
2318358
2318359
2318360
2318361
66543_at
7897295
80835
A_23_P160886
A_23_P160890
GE87791
GO:0004930
GO:0005886
GO:0007165
GO:0007186
GO:0008527
GO:0016020
GO:0016021
GO:0023052
GO:0050877
GO:0050896
GO:0050909
GO:0050912
GO:0050917
GO:0060089
HMNXSV003052521
Hs2.124574.2.S1_3p_a_at
Hs2.124574.4.S1_3p_a_at
ILMN_1805197
PH_hs_0007018
TC01000090.hg
Participates
as a component of
TAS1R1:TAS1R3 [plasma membrane] (Homo sapiens)
Inferred To
Tas1r1 [plasma membrane]
(Mus musculus)
Tas1r1 [plasma membrane]
(Rattus norvegicus)
TAS1R1 [plasma membrane]
(Bos taurus)
TAS1R1 [plasma membrane]
(Canis familiaris)
TAS1R1 [plasma membrane]
(Danio rerio)
TAS1R1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_803884.1
,
NP_619642.2
Guide to Pharmacology - Targets
656
OpenTargets
ENSG00000173662
GeneCards
Q7RTX1
HPA
ENSG00000173662-TAS1R1
Ensembl
ENST00000351136
,
ENSP00000331867
,
ENSP00000312558
,
ENST00000333172
,
ENSG00000173662
PRO
Q7RTX1
Pharos - Targets
Q7RTX1
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