HCAR2 binds HCAR2 ligands

Stable Identifier
R-HSA-444661
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HCAR2 (Niacin receptor 1, GPR109A) is activated by 3-hydroxybutyric acid (Taggart et al. 2005) and niacin (nicotinic acid) (Wise et al. 2003).
Literature References
PubMed ID Title Journal Year
12522134 Molecular identification of high and low affinity receptors for nicotinic acid

Marshall, FH, Ignar, DM, Fraser, NJ, Wise, A, Szekeres, PG, Barnes, AA, Hassall, DG, Dowell, SJ, Pike, NB, Eilert, M, Elshourbagy, N, Wilson, S, Foord, SM, Brown, AJ, Murdock, PR, Steplewski, K, Green, A

J Biol Chem 2003
15929991 (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G

Wu, K, Offermanns, S, Gan, X, Kero, J, Wright, SD, Connolly, D, Taggart, AK, Cheng, K, Kaplan, R, Liaw, C, Ren, N, Wu, TJ, Cai, TQ, Richman, J, Ippolito, M, Chen, R, Jin, L, Waters, MG

J Biol Chem 2005
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!