HCAR2 binds HCAR2 ligands

Stable Identifier
R-HSA-444661
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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HCAR2 (Niacin receptor 1, GPR109A) is activated by 3-hydroxybutyric acid (Taggart et al. 2005) and niacin (nicotinic acid) (Wise et al. 2003).

Literature References
PubMed ID Title Journal Year
15929991 (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G

Taggart, AK, Kero, J, Gan, X, Cai, TQ, Cheng, K, Ippolito, M, Ren, N, Kaplan, R, Wu, K, Wu, TJ, Jin, L, Liaw, C, Chen, R, Richman, J, Connolly, D, Offermanns, S, Wright, SD, Waters, MG

J Biol Chem 2005
12522134 Molecular identification of high and low affinity receptors for nicotinic acid

Wise, A, Foord, SM, Fraser, NJ, Barnes, AA, Elshourbagy, N, Eilert, M, Ignar, DM, Murdock, PR, Steplewski, K, Green, A, Brown, AJ, Dowell, SJ, Szekeres, PG, Hassall, DG, Marshall, FH, Wilson, S, Pike, NB

J Biol Chem 2003
Participants
Participant Of
Orthologous Events
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