HCAR2 binds HCAR2 ligands

Stable Identifier
R-HSA-444661
Type
Reaction
Species
Homo sapiens
Compartment
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HCAR2 (Niacin receptor 1, GPR109A) is activated by 3-hydroxybutyric acid (Taggart et al. 2005) and niacin (nicotinic acid) (Wise et al. 2003).

Literature References
PubMed ID Title Journal Year
12522134 Molecular identification of high and low affinity receptors for nicotinic acid

Marshall, FH, Ignar, DM, Fraser, NJ, Wise, A, Szekeres, PG, Barnes, AA, Hassall, DG, Dowell, SJ, Pike, NB, Eilert, M, Elshourbagy, N, Wilson, S, Foord, SM, Brown, AJ, Murdock, PR, Steplewski, K, Green, A

J Biol Chem 2003
15929991 (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G

Wu, K, Offermanns, S, Gan, X, Kero, J, Wright, SD, Connolly, D, Taggart, AK, Cheng, K, Kaplan, R, Liaw, C, Ren, N, Wu, TJ, Cai, TQ, Richman, J, Ippolito, M, Chen, R, Jin, L, Waters, MG

J Biol Chem 2005
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