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GPR68 [plasma membrane]
Stable Identifier
R-HSA-444625
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OGR1, Sphingosylphosphorylcholine receptor, SPR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR68 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15743 GPR68
Gene Names
GPR68, OGR1
Chain
chain:1-365
Reference Genes
BioGPS Gene:8111 GPR68
COSMIC (genes):GPR68 GPR68
CTD Gene:8111 GPR68
dbSNP Gene:8111 GPR68
ENSEMBL:ENSG00000119714 GPR68
ENSEMBL_homo_sapiens_GENE:ENSG00000119714.11 GPR68
HGNC:4519 GPR68
KEGG Gene (Homo sapiens):8111 GPR68
Monarch:8111 GPR68
NCBI Gene:8111 GPR68
OMIM:601404 GPR68
UCSC:Q15743 GPR68
Reference Transcript
RefSeq:XM_005268110.4 GPR68
RefSeq:XM_011537199.2 GPR68
RefSeq:NM_001177676.1 GPR68
RefSeq:XM_005268112.3 GPR68
RefSeq:XM_011537196.2 GPR68
RefSeq:NM_003485.3 GPR68
RefSeq:XM_011537198.2 GPR68
RefSeq:XM_005268111.3 GPR68
RefSeq:XM_006720262.3 GPR68
RefSeq:NM_001348437.1 GPR68
RefSeq:XM_011537197.2 GPR68
Other Identifiers
11724423_a_at
11724424_at
11752983_a_at
166_at
16795819
211249_PM_at
211249_at
229055_PM_at
229055_at
3576412
3576413
3576414
3576415
3576416
3576417
3576418
3576419
3576420
3576421
3576422
3576424
47146_at
7980765
8111
A_23_P54243
A_24_P931443
GE62288
GO:0002376
GO:0004930
GO:0005886
GO:0006954
GO:0007165
GO:0007186
GO:0016020
GO:0023052
GO:0030073
GO:0030154
GO:0030224
GO:0032024
GO:0035774
GO:0036035
GO:0045656
GO:0048856
GO:0060089
GO:0071467
GO:2001206
HMNXSV003043578
Hs.8882.0.A1_3p_at
ILMN_1671142
PH_hs_0000939
PH_hs_0029296
TC14001435.hg
U48405_at
g1015418_3p_at
Participates
as a member of
pH sensing receptors [plasma membrane] (Homo sapiens)
Inferred To
GPR68 [plasma membrane]
(Bos taurus)
GPR68 [plasma membrane]
(Canis familiaris)
GPR68 [plasma membrane]
(Gallus gallus)
GPR68 [plasma membrane]
(Sus scrofa)
LOC101733637 [plasma membrane]
(Xenopus tropicalis)
Homologues of GPR68 [plasma membrane]
(Xenopus tropicalis)
gpr68 [plasma membrane]
(Xenopus tropicalis)
Gpr68 [plasma membrane]
(Mus musculus)
Gpr68 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
XP_011535501.1
,
XP_005268169.1
,
XP_005268167.1
,
XP_011535498.1
,
XP_011535500.1
,
NP_001171147.1
,
XP_006720325.1
,
XP_005268168.1
,
NP_003476.3
,
NP_001335366.1
,
XP_011535499.1
Guide to Pharmacology - Targets
114
OpenTargets
ENSG00000119714
HPA
ENSG00000119714-GPR68
GeneCards
Q15743
Ensembl
ENSG00000119714
,
ENST00000531499
,
ENST00000650645
,
ENSP00000440797
,
ENSP00000434045
,
ENSP00000498702
,
ENST00000535815
PRO
Q15743
Pharos - Targets
Q15743
Orphanet
25064
HMDB Protein
HMDBP13665
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