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GPR65 [plasma membrane]
Stable Identifier
R-HSA-444624
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Psychosine receptor, PSYR_HUMAN, TDAG8
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
pH sensing receptors [plasma membrane] (Homo sapiens)
GPR65 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IYL9 GPR65
Gene Names
GPR65, TDAG8
Chain
chain:1-337
Reference Genes
BioGPS Gene:8477 GPR65
COSMIC (genes):GPR65 GPR65
CTD Gene:8477 GPR65
dbSNP Gene:8477 GPR65
ENSEMBL:ENSG00000140030 GPR65
HGNC:4517 GPR65
KEGG:hsa:8477 GPR65
Monarch:8477 GPR65
NCBI Gene:8477 GPR65
OMIM:604620 GPR65
UCSC:Q8IYL9 GPR65
Reference Transcript
RefSeq:NM_003608.3 GPR65
Other Identifiers
11731669_at
16787208
214467_PM_at
214467_at
34930_at
3547376
3547377
3547378
3547379
3547380
3547381
3547382
3547383
3547384
3547386
3547387
57374_at
7976080
8477
91364_at
A_14_P120940
A_23_P14564
A_32_P65804
GE523888
GE59594
GE875071
GO:0002376
GO:0004930
GO:0005886
GO:0006915
GO:0006955
GO:0007186
GO:0007189
GO:0007200
GO:0010447
GO:0012501
GO:0016020
GO:0035025
GO:0051496
GO:0060089
GO:0090630
HMNXSV003018145
Hs.131924.0.S1_3p_at
ILMN_1734740
ILMN_2232121
PH_hs_0007855
PH_hs_0021205
TC14000523.hg
Participates
as a member of
pH sensing receptors [plasma membrane] (Homo sapiens)
Inferred To
Gpr65 [plasma membrane]
(Mus musculus)
Gpr65 [plasma membrane]
(Rattus norvegicus)
GPR65 [plasma membrane]
(Bos taurus)
GPR65 [plasma membrane]
(Gallus gallus)
gnrr-4 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003599.2
Guide to Pharmacology - Targets
113
ENSEMBL
ENSP00000267549
,
ENST00000267549
OpenTargets
ENSG00000140030
HPA
ENSG00000140030-GPR65
PRO
Q8IYL9
Pharos - Targets
Q8IYL9
GlyGen
Q8IYL9
HMDB Protein
HMDBP14117
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