Reactome | GPR65 [plasma membrane]

GPR65 [plasma membrane]

Stable Identifier

R-HSA-444624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Psychosine receptor, PSYR_HUMAN, TDAG8

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (q) signalling events (Homo sapiens)
      - Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
      - Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
        
        GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - GPR4, GPR65, GPR132 and OGR1 are pH sensing receptors (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)
        
        pH sensing receptors:H+ [plasma membrane] (Homo sapiens)
        
        pH sensing receptors [plasma membrane] (Homo sapiens)
        
        GPR65 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IYL9 GPR65

Gene Names

GPR65, TDAG8

Chain

chain:1-337

Reference Genes

BioGPS Gene:8477 GPR65

COSMIC (genes):GPR65 GPR65

CTD Gene:8477 GPR65

dbSNP Gene:8477 GPR65

ENSEMBL:ENSG00000140030 GPR65

ENSEMBL_homo_sapiens_GENE:ENSG00000140030.6 GPR65

HGNC:4517 GPR65

KEGG Gene (Homo sapiens):8477 GPR65

Monarch:8477 GPR65

NCBI Gene:8477 GPR65

OMIM:604620 GPR65

UCSC:Q8IYL9 GPR65

Reference Transcript

RefSeq:NM_003608.3 GPR65

Other Identifiers

11731669_at

16787208

214467_PM_at

214467_at

34930_at

3547376

3547377

3547378

3547379

3547380

3547381

3547382

3547383

3547384

3547386

3547387

57374_at

7976080

8477

91364_at

A_14_P120940

A_23_P14564

A_32_P65804

GE523888

GE59594

GE875071

GO:0002376

GO:0004930

GO:0005886

GO:0006915

GO:0006955

GO:0007010

GO:0007165

GO:0007186

GO:0007189

GO:0007200

GO:0010447

GO:0012501

GO:0016020

GO:0023052

GO:0035025

GO:0051496

GO:0060089

GO:0090630

HMNXSV003018145

Hs.131924.0.S1_3p_at

ILMN_1734740

ILMN_2232121

PH_hs_0007855

PH_hs_0021205

TC14000523.hg

Participates

as a member of

pH sensing receptors [plasma membrane] (Homo sapiens)

Inferred To

Gpr65 [plasma membrane] (Mus musculus)

Gpr65 [plasma membrane] (Rattus norvegicus)

GPR65 [plasma membrane] (Bos taurus)

GPR65 [plasma membrane] (Gallus gallus)

gnrr-4 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003599.2

Guide to Pharmacology - Targets

113

OpenTargets

ENSG00000140030

GeneCards

Q8IYL9

HPA

ENSG00000140030-GPR65

Ensembl

ENSP00000267549, ENSG00000140030, ENST00000267549

PRO

Q8IYL9

Pharos - Targets

Q8IYL9

HMDB Protein

HMDBP14117