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MT-RNR2 [extracellular region]
Stable Identifier
R-HSA-444568
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Humanin, HN, HUNIN_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
FPR2 binds FPR2 ligands (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR2:FPR2 ligands [plasma membrane] (Homo sapiens)
FPR2 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPRL2 receptor binds a wide range of ligands (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
FPR3:FPR3 ligands [plasma membrane] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
MT-RNR2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IVG9 MT-RNR2
Gene Names
MT-RNR2, HN
Chain
chain:1-24
Reference Genes
HGNC:7471 MT-RNR2
OMIM:561010 MT-RNR2
UCSC:Q8IVG9 MT-RNR2
Participates
as a member of
FPR2 ligands [extracellular region] (Homo sapiens)
FPR3 ligands [extracellular region] (Homo sapiens)
Cross References
OpenTargets
ENSG00000210082
PRO
Q8IVG9
Pharos - Targets
Q8IVG9
Orphanet
MT-RNR2
PDB
1Y32
,
5GIW
,
7WVX
,
2GD3
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17936 IGFBP3
15
IGFBP3 [endoplasmic reticulum lumen]
(R-HSA-8956748)
p-IGFBP3 [endoplasmic reticulum lumen]
(R-HSA-8956963)
IGFBP3 [extracellular region]
(R-HSA-381512)
IGFBP3(125-233) [extracellular region]
(R-HSA-381465)
IGFBP3(28-124) [extracellular region]
(R-HSA-381547)
IGFBP3(234-291) [extracellular region]
(R-HSA-381546)
IGFBP3(125-187) [extracellular region]
(R-HSA-381507)
IGFBP3(188-291) [extracellular region]
(R-HSA-381471)
IGFBP3(28-168) [extracellular region]
(R-HSA-381489)
IGFBP3(227-291) [extracellular region]
(R-HSA-538718)
IGFBP3(169-226) [extracellular region]
(R-HSA-381499)
IGFBP3(127-291) [extracellular region]
(R-HSA-381455)
IGFBP3(28-126) [extracellular region]
(R-HSA-381534)
IGFBP3(291-187) [extracellular region]
(R-HSA-381410)
IGFBP3(28-186) [extracellular region]
(R-HSA-381454)
0.602
7
UniProt:Q07812 BAX
3
BAX [mitochondrial outer membrane]
(R-HSA-139949)
BAX activated [cytosol]
(R-HSA-139907)
BAX [cytosol]
(R-HSA-139916)
0.593
5
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