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TRH(152-154) [extracellular region]
Stable Identifier
R-HSA-444500
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Thyrotropin releasing hormone, Thyroliberin, TRH_HUMAN, TRH
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Thyrotropin-releasing hormone receptor binds thyrotropin (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
TRH:TRHR [plasma membrane] (Homo sapiens)
TRH [extracellular region] (Homo sapiens)
TRH(152-154) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20396 TRH
Gene Names
TRH
Chain
signal peptide:1-24, chain:25-242, peptide:84-86, peptide:114-116, peptide:135-137, peptide:152-154, peptide:186-188, peptide:227-229
Reference Genes
BioGPS Gene:7200 TRH
COSMIC (genes):TRH TRH
CTD Gene:7200 TRH
dbSNP Gene:7200 TRH
ENSEMBL:ENSG00000170893 TRH
ENSEMBL_homo_sapiens_GENE:ENSG00000170893.4 TRH
HGNC:12298 TRH
KEGG Gene (Homo sapiens):7200 TRH
Monarch:7200 TRH
NCBI Gene:7200 TRH
OMIM:613879 TRH
UCSC:P20396 TRH
Reference Transcript
RefSeq:NM_007117.4 TRH
Other Identifiers
11729493_at
11729494_at
16945451
206622_PM_at
206622_at
2641916
2641919
2641921
2641922
2641923
2641924
32323_at
7200
8082574
A_14_P201049
A_23_P132760
GO:0001692
GO:0005179
GO:0005515
GO:0005576
GO:0007165
GO:0007267
GO:0007628
GO:0008437
GO:0009755
GO:0014050
GO:0014054
GO:0023052
GO:0030141
GO:0031410
GO:0032024
GO:0042755
GO:0043226
GO:0048018
GO:0098772
HMNXSV003015152
ILMN_1694817
M63582_at
PH_hs_0010762
TC03000699.hg
g6005919_3p_at
Participates
as a member of
TRH [extracellular region] (Homo sapiens)
Other forms of this molecule
TRH(135-137) [extracellular region]
TRH(114-116) [extracellular region]
TRH(84-86) [extracellular region]
TRH(186-188) [extracellular region]
TRH(227-229) [extracellular region]
Inferred To
TRH [extracellular region]
(Bos taurus)
TRH [extracellular region]
(Canis familiaris)
TRH [extracellular region]
(Gallus gallus)
TRH [extracellular region]
(Sus scrofa)
Trh [extracellular region]
(Mus musculus)
Trh [extracellular region]
(Rattus norvegicus)
trh [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
NP_009048.1
OpenTargets
ENSG00000170893
GeneCards
P20396
HPA
ENSG00000170893-TRH
Ensembl
ENST00000302649
,
ENSP00000303452
,
ENSG00000170893
PRO
P20396
Pharos - Targets
P20396
Orphanet
15657
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