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FPRL2 receptor binds a wide range of ligands
Stable Identifier
R-HSA-444476
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
FPRL2 receptor binds a wide range of ligands (Homo sapiens)
General
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PNG
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PPTX
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
FPRL2 is activated by the neuroprotective peptide humanin, also an agonist of FPRL1. The peptide F2L is the only reported specific agonist of FPRL2. This is an N-terminal fragment of heme-binding protein. The mechanism of cleavage and secretion of F2L is unknown.
Participants
Input
FPR3 [plasma membrane]
(Homo sapiens)
FPR3 ligands [extracellular region]
(Homo sapiens)
Output
FPR3:FPR3 ligands [plasma membrane]
(Homo sapiens)
Participates
as an event of
Formyl peptide receptors bind formyl peptides and many other ligands (Homo sapiens)
Orthologous Events
FPRL2 receptor binds a wide range of ligands (Canis familiaris)
FPRL2 receptor binds a wide range of ligands (Mus musculus)
FPRL2 receptor binds a wide range of ligands (Rattus norvegicus)
FPRL2 receptor binds a wide range of ligands (Xenopus tropicalis)
Authored
Jupe, S (2009-08-13)
Reviewed
D'Eustachio, P (2009-12-12)
Created
Jupe, S (2009-10-23)
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