Formyl peptide receptors bind formyl peptides and many other ligands

Stable Identifier
R-HSA-444473
Type
Pathway
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Formyl peptide receptors bind formyl peptides and many other ligands
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The formyl peptide receptor (FPR) was defined pharmacologically in 1976 as a high affinity binding site on the surface of neutrophils for the peptide N-formyl-methionine-leucine-phenylalanine (fMLF). FPR was cloned in 1990 and the cDNA used as a probe to identify two additional genes, FPRL1 and FPRL2. The three genes for a cluster on 19q13.3. All are coupled to the Gi family of G proteins.
All 3 receptors can be activated by formyl peptides but also display affinities for a range of structurally diverse ligands.
Literature References
PubMed ID Title Journal Year
17084101 Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses

Communi, D, Migeotte, I, Parmentier, M

Cytokine Growth Factor Rev 2006
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Formyl peptide receptors bind formyl peptides and many other ligands (Xenopus tropicalis)
Authored
Jupe, S  (2009-10-22)
Reviewed
D'Eustachio, P  (2009-12-12)
Created
Jupe, S  (2009-10-23)
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